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TCMBANKHE005961

TCMBank_ID:	TCMBANKHE005961
YEM_ID:	YEM-928
ID:	TCMBANKHE005961/YEM-928
植物拉丁名:	Radix Aconiti Lateralis Preparata\|Aconitum carmichaeli Debx.
功能与主治:	Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect.
药用植物名:	炮附子\|乌头
药名:	乌头
来源:	云南民族药物志：第五卷
药用部位:	Aconitum carmichaeli Debx
使用民族:	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
药味:	Extreme Hot; Pungent; Sweet
经络:	Spleen; Heart; Kidney
毒性:	Toxic
临床特征:	1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow
治疗类型:	温里
TCM_ID_id:	6723
TCMSP_id:	540

植物对应的化合物

化合物ID	化合物名	别名	分子式	分子质量	Smiles

TCMBANKIN001590	coryneine chloride				C[N+](C)(C)CCC1=CC(=C(C=C1)O)O.[I-]
TCMBANKIN047645	aconitine	aconitine ; Aconitine	C34H47NO11	646	C1([H])([H])[C@]([H])(OC([H])([H])[H])[C@]2([C@@]([H])([C@@]([H])([C@]3(OC(C([H])([H])[H])=O)[C@@]([H])([C@@]([H])(OC(=O)c4c([H])c([H])c([H])c([H])c4[H])[C@]([C@]([H])(OC([H])([H])[H])[C@]3([H])O[H])( O[H])C5([H])[H])[C@]25[H])[C@]6([H])OC([H])([H])[H])N(C([H])([H])C([H])([H])[H])C7([H])[H])[C@@]6([H])[C@@]7(C([H])([H])OC([H])([H])[H])[C@]1([H])O[H]
TCMBANKIN048200	hypaconitine	Hypaconitine; aconitine alkaloids	C33H45NO10	616	C1([H])([H])[C@]([H])(OC([H])([H])[H])[C@]2([C@@]([H])([C@@]([H])([C@]3(OC(C([H])([H])[H])=O)[C@@]([H])([C@@]([H])(OC(=O)c4c([H])c([H])c([H])c([H])c4[H])[C@]([C@]([H])(OC([H])([H])[H])[C@]3([H])O[H])( O[H])C5([H])[H])[C@]25[H])[C@]6([H])OC([H])([H])[H])N(C([H])([H])[H])C7([H])[H])[C@@]6([H])[C@@]7(C([H])([H])OC([H])([H])[H])C1([H])[H]
TCMBANKIN049264	mesaconitine		C33H45NO11	632	C1([H])([H])[C@]([H])(OC([H])([H])[H])[C@]2([C@@]([H])([C@@]([H])([C@]3(OC(C([H])([H])[H])=O)[C@@]([H])([C@@]([H])(OC(=O)c4c([H])c([H])c([H])c([H])c4[H])[C@]([C@]([H])(OC([H])([H])[H])[C@]3([H])O[H])( O[H])C5([H])[H])[C@]25[H])[C@]6([H])OC([H])([H])[H])N(C([H])([H])[H])C7([H])[H])[C@@]6([H])[C@@]7(C([H])([H])OC([H])([H])[H])[C@]1([H])O[H]
TCMBANKIN058638	higenamine	UNII-6016M93W29; CHEBI:27751; (R)-Norcoclaurine; 6,7-Dihydroxy-(1R)-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (1R)-; (1R)-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 6016M93W29; SCHEMBL5898913; AX8328517; DTXSID90331552; (+)-HIGENAMINE; UNII-TBV5O16GAP component WZRCQWQRFZITDX-CQSZACIVSA-N; CHEMBL501778; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (R)-; C06347; (R)-(+)-Higenamine; (+)-Demethylcoclaurine; 106032-53-5; BDBM50242856; AC1L9ACA; (1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol; AK00743742; (R)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol; Higenamine, (+)-; ZINC896041; demethylcoclaurine; demetahyl coclaurine	C16H17NO3	271.31 g/mol	C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O

植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

植物对应的靶点

靶点ID	基因名	基因别名	描述	染色体位置	Map_Location	基因类型