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Compound Summary

Compound Information

TCMBANKIN049264

药名:	mesaconitine
分子式:	C33H45NO11
Smiles:	C1([H])([H])[C@]([H])(OC([H])([H])[H])[C@]2([C@@]([H])([C@@]([H])([C@]3(OC(C([H])([H])[H])=O)[C@@]([H])([C@@]([H])(OC(=O)c4c([H])c([H])c([H])c([H])c4[H])[C@]([C@]([H])(OC([H])([H])[H])[C@]3([H])O[H])( O[H])C5([H])[H])[C@]25[H])[C@]6([H])OC([H])([H])[H])N(C([H])([H])[H])C7([H])[H])[C@@]6([H])[C@@]7(C([H])([H])OC([H])([H])[H])[C@]1([H])O[H]
成分:	HBIN034775
OB_score:	8.699915
CAS_id:	2752-64-9
SymMap_id:	SMIT00140
TCMID_id:	13787
TCMSP_id:	MOL002089
PubChem_id:	138115322

化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000047	Plastrum Testudinis Praparata	制龟板			Treatment of hyperactivity of liver yang due to deficient yin of the liver and kidneys manifested as dizziness, distension and pain in the head and blurred vision. Tortoise plastron (Guiban) is used with White peony root (Baishao), Cyathula root (Niuxi), Sea-ear sh/Treatment of hyperactivity of liver yang due to deficient yin of the liver and kidneys manifested as dizziness, distension and pain in the head and blurred vision. Tortoise plastron (Guiban) is used with White peony root (Baishao), Cyathula root (Niuxi),
TCMBANKHE000528	Radix Aconiti Kusnezoffii Preparata	制草乌			Treatment of rheumatic and rheumatoid arthralgia, precordial and abdominal pain with cold sensation, abdominal colic caused by cold, anaethesia./Treatment of rheumatic and rheumatoid arthralgia, precordial and abdominal pain with cold sensation, abdominal colic caused by cold, anaethesia.
TCMBANKHE002581	Bombyx Batryticatus Preparata	制僵蚕			1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chronic convulsions with prolo/1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chr
TCMBANKHE002918	Folium Aconiti Kusnezoffii	草乌叶			To remove toxic heat, and to relieve pain./Treatment of fever in febrile disease, diarrhea and abdominal pain, headache, toothache.
TCMBANKHE003681	Radix Aconiti Kusnezoffii	草乌			To relieve rheumatic conditions, to warm the channels and to alleviate pain./Treatment of rheumatic and rheumatoid arthralgia, precordial and abdominal pain with cold sensation, abdominal colic caused by cold, anaethesia.
TCMBANKHE003690		草乌头
TCMBANKHE003775	Radix Aconiti	川乌			To relieve rheumatic conditions and alleviate pain by warming the channels./Treatment of joint pain in rheumatic or rheumatoid arthritis, epigastric pain with cold sensation, or abdominal colic due to cold, also used as an analgesic in anaesthesis.
TCMBANKHE004022	Cordyceps	冬虫夏草			To tonify the lung and the kidney, arrest bleeding, and dispel phlegm./Impotence and emission, neurasthenia, backache, aching in lumbus and knees, enduring cough and vacuity asthma, taxation damage hemoptysis.
TCMBANKHE004470	Aconitum kusnezoffii	北乌头;草乌			To dispel wind and overcome damp, warm channels and dissipate cold, disperse swelling and relieve pain./Wind-cold-damp impediment, pain in joints, head wind headache, wind stroke with hemiplegia, cold pain in heart and abdomen, cold mounting with pain, knocks and falls, blood stasis swelling and pain, swelling toxin of flat abscess, anesthesia.
TCMBANKHE004539	Fructus Kochiae	地肤子			To remove damp-heat, to dispel zvind, and to relieve itching./Inhibiting the growth of various dermatomyces in vitro.
TCMBANKHE005135	Aconitum napellus	欧乌头
TCMBANKHE006056	Rhizoma Menispermi	北豆根			To remove toxic heat and relieve rheumatic pains./Treatment of sore throat, colitis, dysentery, rheumatic arthralgia.
TCMBANKHE006534	Saccharum sinensis	甘蔗			To clear heat and engender liquid, moisten dryness and harmonize center, resolve toxin./Heat vexation, diabetes mellitus, vomiting nausea, vacuity heat cough, dry stool, swelling of welling abscess, welling abscess and flat abscess with swelling sore.
TCMBANKHE008361		荜茇			Cold pain in stomach duct and abdomen, vomiting, diarrhea, headache, toothache, deep-source nasal congestion, coronary heart disease, angina pectoris.
TCMBANKHE005671/YEM-254	Radix Dichroae\|Dichroa febrifuga Lour.	常山	常山	云南民族药物志：第二卷	To expel phlegm and relieve malaria/Malaria, scrofula.	阿昌族/傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/苗族/佤族/瑶族/彝族
TCMBANKHE005962/YEM-928	Radix Aconiti Lateralis Praeparata\|Aconitum carmichaeli Debx.	制附子\|乌头	乌头	云南民族药物志：第五卷	Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE003980/YEM-928	Aconitum carmichaeli\|Aconitum carmichaeli Debx.	乌头	乌头	云南民族药物志：第五卷	To dispel wind and eliminate damp, warm channels, dissipate cold and relieve pain./Wind-cold-damp impediment, pain in joints, numbness in limbs, hemiplegia, head wind headache, cold pain in heart and abdomen, cold mounting with pain, stasis pain from knocks and falls, swelling toxin of flat abscess.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE005961/YEM-928	Radix Aconiti Lateralis Preparata\|Aconitum carmichaeli Debx.	炮附子\|乌头	乌头	云南民族药物志：第五卷	Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族

植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

化合物对应的靶点

靶点ID	基因名	基因别名	描述