Compound Summary


  Compound Information

药名:

magnoflorine

别名:

NSC150447; AKOS025401511; Magnoflorine; Escholine Iodide; C20H24NO4.I; Magnoflorine, iodide; Thalictrine Iodide; Magnoflorine Iodide (6CI,7CI); N2506; AC-20269; 4H-Dibenzo(de,g)quinolinium, 5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-, iodide, (S)-; Magnoflorine-iodide; NSC 150447; MAGNOFLORINE IODIDE; MAGNOFLORINE IODIDE, (+)-(RG); Magnoflorineiodide; BG01755204; (+)-Magnoflorine Iodide; CHEMBL494052; Corytuberine Methiodide; MolPort-006-069-296; NSC-150447; 4277-43-4; (+)-MAGNOFLORINE IODIDE; 1,11-Dihydroxy-2,10-dimethoxy-6-methyl-6a; AK608288; A-aporphinium Iodide; 8167AH; DTXSID00195420; (6aS)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium Iodide; magnoflorine; (+)-magnoflorine

分子式:

C20H24NO4+

Smiles:

C[N+]1(CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)O)OC)C

成分:

HBIN034216; HBIN034217

OB_score:

26.68763

CAS_id:

2141-09-05

SymMap_id:

SMIT00074

TCMID_id:

13367; 32641

TCMSP_id:

MOL000764;MOL002891;MOL010805

PubChem_id:

73337


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000451 Radix Semiaquilegiae 天葵子 To remove toxic heat and promote the subsidence of swelling./Treatment of carbuncles, boils and sores, mastitis, scrofula, venomous snake bite.
TCMBANKHE000810 Radix Zanthoxyli 两面针 To promote the flow of qi, relieve pain, to eliminate blood stasis, to promote blood circulation and dispel wind./Treatment of traumatic injury, rheumatic arthralgia, stomach-ache, teethache, bitten by venomous snake, applied for burn caused by hot liquid or fire.
TCMBANKHE001149 Caulis Mahoniae 功劳木 To remove dimp-heat, quench fire, and counteract toxicity./Berberine is the main active component with an action similar to Rhizoma Coptidis. Another active component, isotetrandrine, is an anticarcinogenic agent.
TCMBANKHE002046 金果揽 See Tinospora sagittata .
TCMBANKHE002369 Croton cumingii
TCMBANKHE002730 橘络
TCMBANKHE002762 Radix et Rhizoma Thalictri 马尾莲 Influenza, fever in children, common cold with fever, measles papules, malaria, damp-heat diarrhea dysentery, jaundice, red eyes with gall.
TCMBANKHE003021 关黄柏
TCMBANKHE007156 Herba Patriniae 败酱草 1. To eliminate heat and toxic material, relieve abscess and promote pus drainage. 2. To remove blood stasis and alleviate pain/1. Two active components, patrinene and isopatrinene, possess sedative effect. 2. To promote regeneration of hepatic cells and portal circulation, protect hepatic cells from degernation and improve hepatic function.
TCMBANKHE003748 Rhizoma Coptidis 黄连 To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds.
TCMBANKHE003878 Folium Mahoe 十大功劳叶 Tuberculosis and hemoptysis, steaming bone tidal fever, dizziness and tinnitus, limp aching lumbus and knees, damp-heat jaundice, vaginal discharge, dysentery, wind-heat common cold, red eyes with gall, swollen welling abscess and sores.
TCMBANKHE003936 Polyalthia nemoralis 陵水暗罗 To fortify spleen and boost stomach, supplement kidney and secure essence./Center vacuity with stomachache, inappetence, kidney vacuity and emission.
TCMBANKHE005768 Aristolochia moupinensis 淮通
TCMBANKHE004121 Radix Stemoe 百部 1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie.
TCMBANKHE004222 Hypericum curvisepalum 贯叶金丝桃
TCMBANKHE004312 Mahonia japonica 华南功劳木 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE004385 Fructus Aristolochiae 马兜铃 To remove heat from the lung and relieve cough and asthma, and to remove heat from the large intestine./Lung heat cough asthma, phlegm congestion and hasty qi , lung vacuity enduring cough, intestinal heat bleeding from hemorrhoids, swelling pain from hemorrhoids, edema.
TCMBANKHE004608 Magnolia grandiflora 荷花玉兰 To dispel wind and dissipate cold, move qi and relieve pain./Externally contracted wind-cold, headache and nasal congestion, distending pain in stomach duct, vomiting and diarrhea, hypertension, tuberculosis.
TCMBANKHE004610 Ramulus Uncariae cum Uncis 钩藤 To remove heat, subdue hyperactivity of the liver, and arrest convulsions./Infant fright wind and night crying, exuberant heat stirring wind, epilepsy of pregnancy, liver yang dizziness, liver fire headache.
TCMBANKHE006458 Coptis teetoides [Syn. Coptis teeta] 云南黄连 See Coptis chinensis./See Coptis chinensis.
TCMBANKHE004651 Medulla Junci 灯心草 To eliminate excess fire in the heart, and to induce diuresis./Strangury, edema, inhibited urination, damp-heat jaundice, insomnia and vexation, infant night crying, throat impediment, mouth sore, wound.
TCMBANKHE004679 Cocculus pendulus; Cocculus trilobus [Syn. Cocculus sarmentosus] 木防己 To dispel wind and eliminate damp, free channels and quicken network vessels, resolve toxin, disperse swelling and settle pain./Wind-damp impediment pain, pain from arthritis, edema, pulmonary edema, edema due to heart disease, neuralgia, dribbling pain of urination, amenorrhea, knocks and falls, swelling pain in throat, toxin swelling of sores, eczema, poisonous snake bite.
TCMBANKHE004771 Magnolia obovata 日本厚朴
TCMBANKHE004871 Magnolia sprengeri 武当木兰 See Magnolia liliflora./See Magnolia liliflora.
TCMBANKHE004953 Aristolochia debilis [Syn. Aristolochia longa ] 青木香 To lower blood pressure, calm liver and relieve pain, resolve toxin and disperse swelling./Hypertension, gastrospasm, stomachache, infections, chronic bone marrow infection, chronic bronchitis, infection of skin, dizziness and headache, distending pain in chest and abdomen, swollen welling abscess and clove sores, snake or insect bites.
TCMBANKHE005156 Thalictrum baicalense 贝加尔唐松草 See Thalictrum foliolosum ./See Thalictrum foliolosum.
TCMBANKHE005158 淫羊藿 Angina pectoris, chronic bronchitis, neurasthenia, climacteric hypertension, poliomyelitis, impotence and emission, limp wilting sinew and bone, wind-damp impediment pain, hypertonicity and numbness.
TCMBANKHE005181 Cyclea racemosa 轮环藤 To rectify qi and relieve pain, dispel damp and resolve toxin./Distending pain in chest and stomach duct, abdominal pain and diarrhea, wind-damp pain, throat pain, poisonous snake bite, dog bite, swelling toxin of welling abscess and flat abscess, bleeding due to external injury.
TCMBANKHE005202 Berberis thunbergii 日本小檗 To clear heat and dry damp, drain fire and resolve toxin./Damp-heat diarrhea dysentery, stomach heat pain, red eyes with gall, mouth sore, swelling pain in throat, acute eczema, scalds.
TCMBANKHE005207 Thalictrum dasycarpum 粗果唐松草
TCMBANKHE007110 Semen Citri Reticulatae 橘核 To regulate the flow of qi, cause subsidence of modulation, and relieve pain./Mounting qi, painful swollen testes, mammary welling abscess, lumbago, bladder qi pain.
TCMBANKHE007114 Thalictrum minus var. hypoleucum 东亚唐松草
TCMBANKHE005259 Aristolochia heterophylla 汉防己 To dispel wind and relieve pain, clear heat and disinhibit water./Rheumatic pain in joints, damp-heat pain in limbs, edema, inhibited urination, beriberi with edema.
TCMBANKHE007201 Mahonia japonica 华南功劳叶 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE005412 Magnolia denudata [Syn. Magnolia heptapata] 玉兰 See Magnolia liliflora./See Magnolia liliflora.
TCMBANKHE005585 Berberis kawakamii 台湾小菠萝 To clear heat and dry mouth sore, toxin swelling of sores.
TCMBANKHE007866 Coptis deltoidea 三角叶黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE006056 Rhizoma Menispermi 北豆根 To remove toxic heat and relieve rheumatic pains./Treatment of sore throat, colitis, dysentery, rheumatic arthralgia.
TCMBANKHE006761 nodus nelumbinis rhizomatis 藕节 To arrest bleeding and remove blood stasis./Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding.
TCMBANKHE006129 Thalictrum foetidum 香唐松草 To clear heat and dry damp, resolve toxin./Damp-heat dysentery, jaundice, red eyes with gall, swollen welling abscess, sore and boil, wind-damp-heat impediment.
TCMBANKHE006160 Berberis amurensis 小檗;小蘗 To clear heat and dry damp, resolve toxin./Enteritis, dysentery, chronic cholecystitis, acute hepatitis, chronic hepatitis, bacillary dysentery, infection of upper respiratory tract, urinary tract infection, leukopenic complications of carcinoma, innominate toxin swelling, erysipelas, eczema, red eyes, mouth sore.
TCMBANKHE006358 Aristolochia sipho 欧洲马兜铃
TCMBANKHE008697 Caulis Aristolochiae seu Clematis 木通 1. To promote water metabolism and relieve abnormal urination; 2. To clear heat and promote lactation/Acute urethritis, short voidings of reddish urine, strangury-turbidity, edema, nephritis with edema, galactostasis, heat vexation in chest, throat pain, mouth sore, tongue sores, wind-damp impediment pain, galactostasis, amenorrhea, dysmenorrhea.
TCMBANKHE008735 Leontice robustum 红毛七 To quicken blood and dissipate stasis, dispel wind and eliminate damp, move qi and relieve pain./Menstrual disorder, dysmenorrhea, postpartum blood stasis abdominal pain, cold pain in stomach duct and abdomen, knocks and falls, wind-damp impediment pain.
TCMBANKHE006788 Aristolochia fangchi 广防己 To dispel wind and relieve pain, clear heat and disinhibit water./Damp-heat generalized pain, wind-damp impediment pain, edema in lower limb, inhibited urination.
TCMBANKHE006868 Aristolochia contorta 北马兜铃根 See Aristolochia debilis./See Aristolochia debilis.
TCMBANKHE007696 Aristolochia contorta 北马兜铃 See Aristolochia debilis./See Aristolochia debilis.
TCMBANKHE006940 Herba Potentillae Discoloris 翻白草 1. To clear away heat and toxic material. 2. To cool the blood and stop bleeding./Cough and asthma due to lung heat, diarrhea dysentery, malaria, hacking of blood, blood ejection, bloody stool, flooding and spotting [=metrorrhagia and metrostaxis], swelling toxin of welling abscess and sore, scrofula.
TCMBANKHE009006 Caltha palustris 马蹄叶 To expel wind, resolve summerheat, quicken blood and disperse swelling./Wind damage common cold, summerheat stroke with sand, knocks and falls, burns and scalds.
TCMBANKHE007238 Radix Stephaniae Tetrandrae 防己 To cause diuresis and to relieve rheumatic conditions./Beriberi with edema, inhibited urination, eczema, sore toxin, wind-damp impediment pain, hypertension, adjuvant in anesthesia.
TCMBANKHE007303 广藿香 Summerheat-damp lassitude, oppression in chest, vomiting diarrhea with abdominal pain, deep-source nasal congestion and headache.
TCMBANKHE008209 Aristolochia moupinensis 淮通 To clear heat and eliminate damp, dispel wind and relieve pain./Abdominal pain and diarrhea, damp-heat edema, inhibited voidings of reddish urine, hematuria, wind-damp-heat impediment, swollen welling abscess and malign sore, eczema, poisonous snake bite.
TCMBANKHE008359 Semen Oroxyli 木蝴蝶 To remove heat from the lung and relieve sore throat, and to regulate the flow of qi of the liver and the stomach./Lung heat cough, throat impediment, aphonia, liver stomach qi pain.
TCMBANKHE007752 Thalictrum minus 小唐松草
TCMBANKHE007462 青风藤 Wind-damp impediment pain, pain from arthritis, swelling in joints, paralytic and pruritus.
TCMBANKHE007977 Thalictrum thunbergii 烟锅草 To clear heat and resolve toxin, dry damp./Pertussis, toothache, swelling toxin of welling abscess and sore, acute dermitis, eczema.
TCMBANKHE004227/XU-506 Aristolochia manshuriensis 关木通|木通马兜铃 云南省红河州金平县 To clear heart fire, disinhibit urine, free menstruation and milk./Mouth sore, tongue sores, vexation and reddish urine, edema, heat strangury with inhibited pain, leukorrhea, amenorrhea and scant milk, damp-heat impediment pain.
TCMBANKHE004351/YEM-1003 Litsea cubeba|Litsea cubeba(Lour.)Pers. 澄茄子|山鸡椒 木姜子 云南民族药物志:第五卷 To warm center and relieve pain, move qi and quicken blood, calm asthma, disinhibit urine./Chronic bronchitis, bronchial asthma, asthma, cold pain in stomach duct and abdomen, food accumulation and qi distention, stomach reflux vomiting, summerheat stroke with vomiting and diarrhea, diarrhea, cold mounting with abdominal pain, cold-damp water drum distention, inhibited urination, opacity of urine, toxin swelling of sores, toothache, cold-damp impediment pain, knocks and falls. 傣族/德昂族/景颇族/傈僳族/水族/佤族/彝族/壮族
TCMBANKHE003785/YEM-1014 Phellodendron chinense|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄皮树|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 See Phellodendron amurense./See Phellodendron amurense. 瑶族/壮族
TCMBANKHE004238/YEM-1014 Phellodendron amurense;Cortex Phellodendri|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄柏|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 1. To clear heat and dry dampness; 2. To reduce fire and release toxins/Damp-heat dysentery, tuberculosis, epidemic meningitis, acute conjunctivitis, trachoma, fever, abdominal pain, diarrhea, suppurative hematochezia, tenesmus, jaundice, yellow thick foul leukorrhagia, swelling pain in knees and feet, urinary tract infection, boil, sore, ulcer, eczema, mouth sore, hemorrhoids, burns, scalds, exuberance of fire with tidal fever, tidal fever with night sweat, emission. 瑶族/壮族
TCMBANKHE002460/YEM-1014 Phellodendron chinense var. glabriusculum|Phellodendron chinense Schneid var.glabriusculum Schneid. 土叶黄皮树|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 See Phellodendron amurense./See Phellodendron amurense. 瑶族/壮族
TCMBANKHE000631/YEM-135 herba meconpsis integrifoliae|Meconopsis integrifolia(Maxim.) Franch. 绿绒蒿|全缘叶绿绒蒿 全缘叶绿绒蒿 云南民族药物志:第一卷 傈僳族/藏族
TCMBANKHE000649/YEM-168 Cortex Berberidis|Berberis wilsonae Hemsl. 三颗针|金花小檗 小三颗针 云南民族药物志:第一卷 For clearing heat and removing toxic substances 傈僳族/彝族
TCMBANKHE005228/YEM-235 Cortex Magnoliae officilis;Magnolia officinalis|Magnolia officinalis Rehd.et Wils. 厚朴 厚朴 云南民族药物志:第二卷 To eliminate damp and relieve distension;To dry damp and disperse phlegm, precipitate qi and eliminate fullness, lower blood pressure./1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate.5.Amebic dysentery, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distention and constipation, phlegm-rheum cough asthma. 彝族
TCMBANKHE004240/YEM-586 Magnolia rostrata|Magnolia rostrata W.W.Sm. 大叶厚朴|长喙厚朴 贡山厚朴 云南民族药物志:第三卷 To warm center and transform damp, move qi and disperse accumulation./Distention fullness and sudden pain in chest and abdomen, food accumulation and qi stagnation, vomiting, diarrhea, cough with profuse phlegm. 傈僳族
TCMBANKHE008695/YEM-708 Mahonia fortunei|Mahonia fortunei(Lindl.)Fedde 细叶功劳木|十大功劳 十大功劳 云南民族药物志:第四卷 See Mahonia bealei./See Mahonia bealei. 布依族/傣族/苗族/瑶族/彝族/壮族
TCMBANKHE004819/YEM-708 Mahonia fortunei|Mahonia fortunei(Lindl.)Fedde 细叶功劳叶|十大功劳 十大功劳 云南民族药物志:第四卷 See Mahonia bealei./See Mahonia bealei. 布依族/傣族/苗族/瑶族/彝族/壮族
TCMBANKHE006083/YEM-791 Herba Aristolochiae;Fibraurea recisa Pierre|Fibraurea recisa Pierre 天仙藤 大黄藤 云南民族药物志:第四卷 To promote the flow of qi and blood, and to induce diuresis./Acute tonsillitis, pharyngolaryngitis, infection of upper respiratory tract, conjunctivitis, jaundice, gastroenteritis, dysentery, child indigestion, food poisoning, salpingitis, acute endometritis, chronic endometritis, acute pelvic inflammation, vaginitis, sore and boil, burns and scalds. 瑶族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000121 KCNH2 ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000474 NCOA1 F-SRC-1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 nuclear receptor coactivator 1
TCMBANKGE000476 NCOA2 GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75 nuclear receptor coactivator 2
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE001007 NR1I2 BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR nuclear receptor subfamily 1 group I member 2
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001506 ADRA1B ADRA1; ALPHA1BAR adrenoceptor alpha 1B
TCMBANKGE001943 ADRA1D ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 adrenoceptor alpha 1D
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE005535 CHRM1 HM1; M1; M1R cholinergic receptor muscarinic 1
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE006943 CHRM3 EGBRS; HM3; PBS cholinergic receptor muscarinic 3
TCMBANKGE008702 OPRM1 LMOR; M-OR-1; MOP; MOR; MOR1; OPRM opioid receptor mu 1
TCMBANKGE008921 RXRA NR2B1 retinoid X receptor alpha
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1
TCMBANKGE014625 OPRD1 DOP; DOR; DOR1; OPRD opioid receptor delta 1