Compound Summary


  Compound Information

药名:

higenamine

别名:

UNII-6016M93W29; CHEBI:27751; (R)-Norcoclaurine; 6,7-Dihydroxy-(1R)-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (1R)-; (1R)-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 6016M93W29; SCHEMBL5898913; AX8328517; DTXSID90331552; (+)-HIGENAMINE; UNII-TBV5O16GAP component WZRCQWQRFZITDX-CQSZACIVSA-N; CHEMBL501778; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (R)-; C06347; (R)-(+)-Higenamine; (+)-Demethylcoclaurine; 106032-53-5; BDBM50242856; AC1L9ACA; (1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol; AK00743742; (R)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol; Higenamine, (+)-; ZINC896041; demethylcoclaurine; demetahyl coclaurine

分子式:

C16H17NO3

Smiles:

C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O

成分:

HBIN029382;HBIN023239;HBIN024304

CAS_id:

5843-65-2

SymMap_id:

SMIT01691;SMIT14979;SMIT18586

TCMID_id:

23264;23842;5066;24322

PubChem_id:

114840


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000350 Receptaculum Nelumbinis 莲房 To remove blood stasis and arrest bleeding./Treatment of abnormal uterine bleeding, hematurial hemorrhoidal bleeding, postpartum blood stasis, lochiorrhea.
TCMBANKHE000518 少果吴茱萸
TCMBANKHE001184 毛脉吴茱萸
TCMBANKHE001720 买麻藤
TCMBANKHE002237 Stamen Nelumbinis 莲须 To astringe the kindey and arrest spontaneous emission./Treatment of seminal emission, spermatorrhea, excessive leukorrhea, frequent urination.
TCMBANKHE002277 荷花
TCMBANKHE002301 莲衣
TCMBANKHE002581 Bombyx Batryticatus Preparata 制僵蚕 1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chronic convulsions with prolo/1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chr
TCMBANKHE003028 粉萆薢 Treatment of chyluria, turbid urine mixed with whitish substance or whitish discharge from urethra, excessive leukorrhea, rheumatic arthralgia with limitation of motion and pain in the loins and knees.
TCMBANKHE003297 Oleum Vanillae 香草香精
TCMBANKHE003690 草乌头
TCMBANKHE003720 herba centellae 积雪草 To remove heat and damp, to counteract toxicity, and to cause subsidence of swelling./Sand qi abdominal pain, summerheat-heat diarrhea, dysentery, damp-heat jaundice, sand strangury, blood strangury, blood ejection, spontaneous external bleeding, red eyes, swollen throat, wind papules, scab and lichen, swelling toxin of clove welling abscess, knocks and falls, hypertension.
TCMBANKHE003730 Gentiana scabra var. buesgeri 龙胆 Acute icterohepatitis, urinary tract infection, acute conjunctivitis, dribbling pain of urination, damp-heat jaundice, genital swelling and itch, damp-heat vaginal discharge, distended head and headache due to liver-gallbladder repletion fire, red eyes with gall, deafness, swelling in ear, pain in rib-side, bitter taste, fright wind and convulsion.
TCMBANKHE003743 Radix Astragali 黄芪 To reinoforce qi and invigorate the function of the spleen./Common cold, influenza, chronic wound ulcer, chronic glomerulonephritis, diabetes mellitus due to internal heat, qi vacuity edema, chronic gastritis, qi vacuity and hypodynamia, reduced food intake and sloppy stool, center qi fall, chronic diarrhea, prolapse of rectum, hematochezia, flooding and spotting, spontaneous sweating due to exterior vacuity.
TCMBANKHE003748 Rhizoma Coptidis 黄连 To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds.
TCMBANKHE003775 Radix Aconiti 川乌 To relieve rheumatic conditions and alleviate pain by warming the channels./Treatment of joint pain in rheumatic or rheumatoid arthritis, epigastric pain with cold sensation, or abdominal colic due to cold, also used as an analgesic in anaesthesis.
TCMBANKHE004022 Cordyceps 冬虫夏草 To tonify the lung and the kidney, arrest bleeding, and dispel phlegm./Impotence and emission, neurasthenia, backache, aching in lumbus and knees, enduring cough and vacuity asthma, taxation damage hemoptysis.
TCMBANKHE004086 Plumula Nelumbinis 莲子心 To remove heat from the heart and calm the nerves, to restore the coordination between the heart and the kidney, to check emission, and to arrest bleeding./Heat entering pericardium, clouded spirit with delirious speech, non-interaction of heart and kidney, insomnia and emission, blood ejection due to blood heat, hypertension.
TCMBANKHE004319 Herba ErodiiHerba Geranii 老鹳草 To remove obstruction of channels and collaterals, relieve rheumatic conditions, and arrest diarrhea./Wind-damp impediment pain, hypertonicity and numbness, aching sinews and bones, diarrhea and dysentery.
TCMBANKHE004327 Gnetum parvifolium [Syn. Gnetum indicum ] 小叶荬麻藤 To dispel wind and eliminate damp, stanch bleeding and dissipate stasis, relieve cough and transform phlegm./Wind-damp impediment pain, lumbago, crane’s knee wind, knocks and falls, ulcerative bleeding, chronic trachitis.
TCMBANKHE006128 Radix Gentiae macrophyllae 秦艽 To relieve rheumatic conditions, and to remove damp-heat./Wind-damp impediment pain, hypertonicity of sinews and vessels, aching pain in joints, late afternoon tidal fever, child gan accumulation with fever.
TCMBANKHE004539 Fructus Kochiae 地肤子 To remove damp-heat, to dispel zvind, and to relieve itching./Inhibiting the growth of various dermatomyces in vitro.
TCMBANKHE004755 Semen Impatientis 急性子 To remove stagnation of qi, eliminate blood stasis, and soften hard masses./Concretion and conglomeration, lump glomus, amenorrhea, dysphagia-occlusion.
TCMBANKHE004791 Herba Spirodelae 浮萍 To dispel wind-heat, to promote eruption, and to cause diuresis./Wind-heat exterior syndrome, non-eruption of measles, dormant papules with pruritus, edema, dribbling urinary block, sore and lichen, erysipelas, scalds.
TCMBANKHE007536 天雄
TCMBANKHE007537 侧子
TCMBANKHE007481 Cephalotaxus hainanensis [Syn. Cephalotaxus mannii ] 海南粗榧 Anticancer./Carcinoma.
TCMBANKHE005823 Herba Alternantherae 莲子草 Its injection inhibits the growth of Asia influenza A virus, encephalitis B virus and rabies virus in vitro./Its injection inhibits the growth of Asia influenza A virus, encephalitis B virus and rabies virus in vitro.
TCMBANKHE008642 Murraya paniculata [Syn. Chalcas paniculata] 九里香 To move qi and quicken blood, dissipate stasis and relieve pain, resolve toxin and disperse swelling, anesthetize and settle pain./Pain in stomach duct, wind-damp impediment pain, painful swelling from knocks and falls, sore and welling abscess, snake or insect bites, local anesthesia.
TCMBANKHE005949 Rhizoma Polygoti 黄精 To reinforce qi and nourish yin, to invigorate the function of the spleen, to moisten the lung, and to benefit the kidney./Yin vacuity taxation cough, lung heat dry cough, fatigue hypodynamia due to spleen vacuity, reduced food intake with dry mouth, diabetes mellitus, limp aching lumbus and knees due to kidney yin vacuity, impotence and emission, tinnitus and dim vision, premature graying in beard and hair, vacuity and marked emaciation, wind lai lichen.
TCMBANKHE006061 Fructus Evodiae 吴茱萸 1. To dispel cold and stop pain; 2. To pacify the liver and direct rebellious qi downward; 3. To stop vomiting/Dysentery, cold pain in stomach duct and abdomen, reverting yin headache, mounting qi , dysmenorrhea, beriberi with edema, hyperchlorhydria, cold-damp diarrhea.
TCMBANKHE006761 nodus nelumbinis rhizomatis 藕节 To arrest bleeding and remove blood stasis./Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding.
TCMBANKHE008870 Aconitum japonicum 日本乌头
TCMBANKHE006546 Cephalotaxus fortunei 三尖杉 Anticancer./Carcinoma of stomach, carcinoma of rectum, carcinoma of lung, carcinoma of esophagus, lymphatic sarcoma, leukaemia.
TCMBANKHE007781 Herba Asari 细辛 To dispel wind-cold, to relieve nasal obstruction, to alleviate pain and to remove retained fluid./Wind-cold common cold, influenza, headache, toothache, local anesthesia, nasal congestion, deep-source nasal congestion, wind-damp impediment pain, phlegm-rheum cough asthma.
TCMBANKHE006963 Cephalotaxus sinensis [Syn. Cephalotaxus harringtonia var. sinensis ] 中国粗榧枝叶 Anticancer./Carcinoma.
TCMBANKHE007734 Fructus Tribuli 蒺藜 To subdue hyperactivity of the liver, to promote blood circulation, to dispel wind, to clear the eye of opacity, and to arrest itching./1. Antitussive, expectorant and antiasthmatic. 2. Its alcoholic infusion exerts hypotensive effect in anesthetized animals.
TCMBANKHE009154 Radix Gentiae macrophyllae 秦艽 To relieve rheumatic conditions, and to remove damp-heat./Wind-damp impediment pain, hypertonicity of sinews and vessels, aching pain in joints, late afternoon tidal fever, child gan accumulation with fever.
TCMBANKHE005824/XU-618 Herba Alternantherae|Alternanthera philoxeroides 空心莲子草|喜旱莲子草(空心莲子草) 云南省昭通市盐津县 To clear heat and toxic materials, promote diuresis. For heat-syndrome, intense heat-syndrome and dampness-heat syndrome. Recently, for preventing and treating encephalitis B, epidemic ho\emorrhagic fever, viral hepatitis, eyedrops for epidemic conjunctivitis and viral keratitis, local application for herpes zoster. Also for furuncle, snake bite, stranguria with turbid urine, etc./To clear heat and toxic materials, promote diuresis. For heat-syndrome, intense heat-syndrome and dampness-heat syndrome. Recently, for preventing and treating encephalitis B, epidemic ho\emorrhagic fever, viral hepatitis, eyedrops for epidemic conjunctiv
TCMBANKHE008259/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 荷梗|莲 云南民族药物志:第一卷 To dispel summerheat, rectify qi and transform damp./Summerheat-damp and oppression in chest, diarrhea, dysentery, strangury, Vaginal discharge. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005257/YEM-104 Folium Nelumbinis|Nelumbo nucifera Gaertn. 荷叶|莲 云南民族药物志:第一卷 To relieve summer-heat, to invigorate the spleen function of the spleen and arrest bleeding by reducing heat in blood./Summerheat-heat vexation and thirst, summerheat-damp diarrhea, spleen vacuity diarrhea, blood heat, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE002779/YEM-104 Succus Rhizoma Lotus|Nelumbo nucifera Gaertn. 藕汁|莲 云南民族药物志:第一卷 Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding./Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005111/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 荷叶蒂|莲 云南民族药物志:第一卷 To clear summerheat and eliminate damp, dispel stasis and stanch bleeding, quiet fetus./Summerheat-damp diarrhea, blood dysentery, flooding and spotting, stirring fetus in pregnancy. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE006652/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 莲子|莲 云南民族药物志:第一卷 To supplement spleen and check diarrhea, boost kidney and secure essence, nourish heart and quiet spirit./Chronic diarrhea, inappetence, emission, restlessness, fright palpitation, insomnia, flooding and spotting, excessive leukorrhea. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE007683/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 藕|莲 云南民族药物志:第一卷 To clear heat and engender liquid, cool blood, stanch bleeding and dissipate stasis./Febrile diseases with vexation and thirst, blood ejection, spontaneous external bleeding, precipitate blood. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE003242/YEM-104 Semen Nelumbinis|Nelumbo nucifera Gaertn. 石莲子|莲 云南民族药物志:第一卷 Treatment of protracted diarrhea due to hypofunction of the spleen, seminal emission, leukorrhagia, palpitation, insomnia./Treatment of protracted diarrhea due to hypofunction of the spleen, seminal emission, leukorrhagia, palpitation, insomnia. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE004506/YEM-137 Radix Notoginseng|Panax notoginseng (Burk.) F, H. Chen ex C.Chow et al. 三七 三七 云南民族药物志:第一卷 To eliminate blood stasis, arrest bleeding, cause subsidence of swelling and alleviate pain./Hemoptysis, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting, bleeding due to external injury, angina pectoris, stabbing pain in chest and abdomen, painful swelling from knocks and falls. 彝族
TCMBANKHE005671/YEM-254 Radix Dichroae|Dichroa febrifuga Lour. 常山 常山 云南民族药物志:第二卷 To expel phlegm and relieve malaria/Malaria, scrofula. 阿昌族/傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/苗族/佤族/瑶族/彝族
TCMBANKHE003733/YEM-396 Melia azedarach 莲花|棟 苦棟皮 云南民族药物志:第二卷 To clear heat and dispel damp, kill worms and relieve itch./Prickly heat. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/普米族/佤族/瑶族/彝族/壮族
TCMBANKHE007773/YEM-590/XU-716 Ramulus Mori|Morus alba L.|Morus alba 桑枝|桑 桑叶 云南民族药物志:第三卷|云南省昭通市盐津县 To relieve rheumatic arthralgia./Hypertension, aching pain in joints, numbness in joints. 阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族
TCMBANKHE003980/YEM-928 Aconitum carmichaeli|Aconitum carmichaeli Debx. 乌头 乌头 云南民族药物志:第五卷 To dispel wind and eliminate damp, warm channels, dissipate cold and relieve pain./Wind-cold-damp impediment, pain in joints, numbness in limbs, hemiplegia, head wind headache, cold pain in heart and abdomen, cold mounting with pain, stasis pain from knocks and falls, swelling toxin of flat abscess. 阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE005961/YEM-928 Radix Aconiti Lateralis Preparata|Aconitum carmichaeli Debx. 炮附子|乌头 乌头 云南民族药物志:第五卷 Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect. 阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE007564/YEM-928 Aconitum carmichaeli Debx. 漏篮子|乌头 乌头 云南民族药物志:第五卷 阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE005962/YEM-928 Radix Aconiti Lateralis Praeparata|Aconitum carmichaeli Debx. 制附子|乌头 乌头 云南民族药物志:第五卷 Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect. 阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI006641 Myocardial Reperfusion Injury phenotype Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases 26746354

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000046 PIK3R1 AGM7; GRB1; IMD36; p85; p85-ALPHA phosphoinositide-3-kinase regulatory subunit 1
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000139 POR CPR; CYPOR; P450R cytochrome p450 oxidoreductase
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000276 NOS1 IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS nitric oxide synthase 1
TCMBANKGE000305 PIK3CD APDS; IMD14; P110DELTA; PI3K; p110D phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
TCMBANKGE000306 PIK3CG PI3CG; PI3K; PI3Kgamma; PIK3; p110gamma; p120-PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
TCMBANKGE000307 PIK3CB P110BETA; PI3K; PI3KBETA; PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
TCMBANKGE000308 PIK3CA CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; PI3K; PI3K-alpha; p110-alpha phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
TCMBANKGE000330 HMOX1 HMOX1D; HO-1; HSP32; bK286B10 heme oxygenase 1
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE001107 NOS3 ECNOS; eNOS nitric oxide synthase 3
TCMBANKGE001131 CASP9 APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 caspase 9
TCMBANKGE001156 CASP3 CPP32; CPP32B; SCA-1 caspase 3
TCMBANKGE006373 TYW1 RSAFD1; TYW1A; YPL207W tRNA-yW synthesizing protein 1 homolog
TCMBANKGE009863 MTRR MSR; cblE 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
TCMBANKGE011356 NDOR1 CIAE1; NR1; bA350O14.9 NADPH dependent diflavin oxidoreductase 1
TCMBANKGE014693 ADRB3 BETA3AR adrenoceptor beta 3
TCMBANKGE014790 ADRB1 ADRB1R; B1AR; BETA1AR; FNSS2; RHR adrenoceptor beta 1