Compound Summary


  Compound Information

药名:

rottlerin

分子式:

C30H28O8

Smiles:

CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C(=C3C(=C2O)C=CC(O3)(C)C)C(=O)C=CC4=CC=CC=C4)O)O

成分:

HBIN042467;HBIN034326

CAS_id:

30169

SymMap_id:

SMIT17499

TCMID_id:

18925

PubChem_id:

5281847


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000121 西藏酸模
TCMBANKHE000753 鼠李皮
TCMBANKHE001421 波叶大黄
TCMBANKHE004552 Rumex dentatus 牛舌草 To clear heat and resolve toxin, kill worms and relieve itch./Red swollen breast.
TCMBANKHE001849 倒扣草
TCMBANKHE002516 野花生
TCMBANKHE002565 鼠李根
TCMBANKHE002866 山扁豆
TCMBANKHE003373 Exocarpium Citri grandis 化橘红 To dispel cold, eliminate damp and phlegm, and arrest emesis or nausea./Treatment of cough, itching of the throat and profuse expectoration in colds, nausea, vomiting and epigastric distension caused by improper diet or excessive drinking.
TCMBANKHE003426 Fructus Leonuri 茺蔚子 To activate blood circulation and regulate menstruation, to subdue hyperactivity of the liver, and to clear the eye of opacity./Treatment of menstrual disorders, amenorrhea, hysmenorrhea, inflammation of the eye with formation of corneal opacity, dizziness and headache.
TCMBANKHE003605 大黄茎
TCMBANKHE003723 Flos Lonicerae 金银花 To remove toxic heat and dispel wind-heat./Infection of upper respiratory tract, tonsillitis, acute laryngitis, skin suppurations, welling abscess, viral conjunctivitis, influenza, pneumonia, mastitis, acute appendicitis, warm disease fever, heat toxin blood dysentery, swollen welling abscess and clove sores, throat impediment.
TCMBANKHE003738 Aloe 芦荟 1. To purge feces; 2. To clear heat in the liver; 3. To kill worms/Constipation, child gan accumulation, ascariasis, fright wind, lichen.
TCMBANKHE003822 Rumex patientia 牛西西 To clear heat and resolve toxin, stanch bleeding and disperse swelling, free stool and kill worms./Blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting, red and white vaginal discharge, purpura, dysentery, hepatitis, constipation, inhibited urination, swelling toxin of welling abscess and sore, scab and lichen, knocks and falls, burns and scalds.
TCMBANKHE003911 Folium Sene 番泻叶 To purge feces downward/Heat bind and accumulation, constipation w ith abdominal pain, edema distention fullness.
TCMBANKHE004160 Semen Cassiae;Semen Sene 决明子 To remove heat from the liver, to improve eyesight, and to relax bowels./See Cassia obtusifolia.
TCMBANKHE004176 Derris elliptica 毛鱼藤
TCMBANKHE006301 Mallotus philippinensis 吕宋楸毛 To kill worms and relieve diarrhea./Taeniasis, ascariasis, oxyuria disease.
TCMBANKHE006313 Radix et Rhizoma Rhei 大黄 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE009105 Cassia mimosoides 山扁豆子 To clear heat and resolve toxin, fortify spleen and disinhibit damp, free stool./Jaundice, summerheat-heat and vomiting diarrhea, child gan accumulation, edema, inhibited urination, habitual constipation, poisonous snake bite.
TCMBANKHE005641 Millettia reticulata 鸡血藤根 To quiet spirit, calm./Manic agitation schizophrenia.
TCMBANKHE006028 Rhamnus davurica 鼠李 To clear heat and resolve toxin, drain precipitation and kill worms, relieve cough and dispel phlegm./Sore and welling abscess, scrofula, scab and lichen, decayed toothache, mout h sore, abdominal distention and constipation, cough of phlegm asthma, edema distention fullness.
TCMBANKHE007894 Derris trifoliata 鱼藤 To dissipate stasis and relieve pain, kill worms and relieve itch./Painful swelling from knocks and falls, lichen.
TCMBANKHE008819 Tephrosia purpurea 灰叶根 To clear heat and disperse stagnation, move qi and relieve pain, contract damp and relieve itch./Indigestion, gastritis, abdominal distention, stomachache, eczema, dermatitis.
TCMBANKHE006959/YNS-135/YEM-14 Semen Cassiae;Semen Sene|Cassia tora Linn.|Cassia tora L. 决明子;草决明|决明 决明根|草决明 云南药材标准:第三册|云南民族药物志:第一卷 安神补脑,清肝明目,理气止痛。主治失眠多梦,入睡易惊,腹内痉挛剧痛,腹部包块,黄疸,疟疾。|To remove heat from the liver, to improve eyesight, and to relax bowels.Treatment of inflammation in the eye with pain, photophobia and lacrimination, headache, dizziness, blurred vision and constipation./See Cassia obtusifolia.1. Oral adminstration of the hearbal powder can inhibit the rising of serum cholesterol and formation of atherosclerosis in rabbits.2. Its tincture and infusion can inhibit the myocardium of toad in vitro, and contract th eblood vessels of lower limbs.3. Its infusion can lower the blood pressure in dogs, cats and rabbits.4. Chrysophanol, one of the active components, is a laxative.5. Bacteriostatic. 傣族/基诺族/拉祜族/傈僳族/苗族/佤族/彝族/藏族
TCMBANKHE005278/YEM-158 Cassia occidentalis|Cassia occidentalis L. 望江南 望江南 云南民族药物志:第一卷 To clear lung, clear liver, calm asthma, disinhibit urine, free stool, resolve toxin and disperse swelling, lower blood pressure./Cough and asthma, hypertension, headache and red eyes, dribbling urination, constipation, swelling toxin of welling abscess and sore, snake or insect bites. 阿昌族/傣族/德昂族/景颇族/傈僳族
TCMBANKHE006292/YNS-298/YEM-187/XU-40/XU-99 Verbascum thapsus|Verbascum thapsus L|Verbascum thapsus L. 毛蕊花 一柱香 云南药材标准:第六册|云南民族药物志:第一卷|云南省昆明市盘龙区 清热解毒,活血止血。用于肺热咳嗽,湿热痹痛,肠痈,疮毒,湿疹,跌打扭伤,创伤出血。|To clear heat and resolve toxin, stanch bleeding and dissipate stasis./Pneumonia, chronic appendicitis, sore toxin, sprain from knocks and falls, bleeding due to external injury. 白族/傈僳族/纳西族/彝族/藏族
TCMBANKHE008066/YEM-321 Pachyrhizus erosus|Pachyrhizus erosus (L.)Urb. 地瓜子|豆薯 豆薯 云南民族药物志:第二卷 To kill worms and relieve itch./Scab and lichen, itchy skin, swollen welling abscess. 傣族
TCMBANKHE008340/YEM-321 Pachyrhizus erosus|Pachyrhizus erosus (L.)Urb. 地瓜子|豆薯 豆薯 云南民族药物志:第二卷 To kill worms and relieve itch./Scab and lichen, itchy skin, swollen welling abscess. 傣族
TCMBANKHE007363/YEM-744/XU-850 Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum 大黄; 生锦纹; 生军|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE008805/YEM-805/XU-448 Millettia pachycarpa|Millettia pachycarpa Benth. 苦檀子|厚果崖豆藤 冲天子 云南民族药物志:第四卷|云南省昭通市盐津县普洱镇 To attack toxin and relieve pain, disperse accumulation and kill worms./Scab and lichen, sore lai, sand qi abdominal pain, child gan accumulation. 布依族/傈僳族/彝族/藏族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000007 melanoma disease Neoplasms 27343979
TCMBANKDI000018 Pancreatic Neoplasm disease Digestive System Diseases; Neoplasms; Endocrine System Diseases 25050737
TCMBANKDI000022 Prostatic Neoplasms group Neoplasms; Male Urogenital Diseases 24125861
TCMBANKDI000076 Adenocarcinoma group Neoplasms 25661734
TCMBANKDI000078 Skin Neoplasms group Neoplasms; Skin and Connective Tissue Diseases 27343979
TCMBANKDI000089 Asthma disease Respiratory Tract Diseases; Immune System Diseases 23995289
TCMBANKDI015740 Colorectal Neoplasms group Digestive System Diseases; Neoplasms 28570591
TCMBANKDI031697 Hyperpigmentation phenotype Skin and Connective Tissue Diseases 31176710
TCMBANKDI032090 Liver Neoplasms, Experimental phenotype Digestive System Diseases; Neoplasms 28570591

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000046 PIK3R1 AGM7; GRB1; IMD36; p85; p85-ALPHA phosphoinositide-3-kinase regulatory subunit 1
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000198 KCNMA1 BKTM; CADEDS; IEG16; KCa1.1; LIWAS; MaxiK; PNKD3; SAKCA; SLO; SLO-ALPHA; SLO1; bA205K10.1; hSlo; mSLO1 potassium calcium-activated channel subfamily M alpha 1
TCMBANKGE000228 CRTC1 MAML2; MECT1; Mam-2; TORC-1; TORC1; WAMTP1 CREB regulated transcription coactivator 1
TCMBANKGE000269 ATG5 APG5; APG5-LIKE; APG5L; ASP; SCAR25; hAPG5 autophagy related 5
TCMBANKGE000305 PIK3CD APDS; IMD14; P110DELTA; PI3K; p110D phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
TCMBANKGE000306 PIK3CG PI3CG; PI3K; PI3Kgamma; PIK3; p110gamma; p120-PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
TCMBANKGE000307 PIK3CB P110BETA; PI3K; PI3KBETA; PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
TCMBANKGE000308 PIK3CA CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; PI3K; PI3K-alpha; p110-alpha phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
TCMBANKGE000373 ATG12 APG12; APG12L; FBR93; HAPG12 autophagy related 12
TCMBANKGE000374 CDK6 MCPH12; PLSTIRE cyclin dependent kinase 6
TCMBANKGE000375 MACC1 7A5; SH3BP4L MET transcriptional regulator MACC1
TCMBANKGE000376 CRTC3 TORC-3; TORC3 CREB regulated transcription coactivator 3
TCMBANKGE000377 MITF CMM8; COMMAD; MI; WS2; WS2A; bHLHe32 melanocyte inducing transcription factor
TCMBANKGE000647 ATG7 APG7-LIKE; APG7L; GSA7 autophagy related 7
TCMBANKGE000727 MAP1LC3A ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3 microtubule associated protein 1 light chain 3 alpha
TCMBANKGE000809 BIRC3 AIP1; API2; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49; c-IAP2 baculoviral IAP repeat containing 3
TCMBANKGE000855 NKX3-1 BAPX2; NKX3; NKX3.1; NKX3A NK3 homeobox 1
TCMBANKGE000912 SHH HHG1; HLP3; HPE3; MCOPCB5; SMMCI; ShhNC; TPT; TPTPS sonic hedgehog signaling molecule
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE000979 KDR CD309; FLK1; VEGFR; VEGFR2 kinase insert domain receptor
TCMBANKGE000987 COL11A2 DFNA13; DFNB53; FBCG2; HKE5; OSMEDA; OSMEDB; PARP; STL3 collagen type XI alpha 2 chain
TCMBANKGE001037 MMP2 CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1 matrix metallopeptidase 2
TCMBANKGE001045 CCND1 BCL1; D11S287E; PRAD1; U21B31 cyclin D1
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001089 PARP1 ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1 poly(ADP-ribose) polymerase 1
TCMBANKGE001106 MTOR FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS mechanistic target of rapamycin kinase
TCMBANKGE001112 PRKAB1 AMPK; HAMPKb protein kinase AMP-activated non-catalytic subunit beta 1
TCMBANKGE001118 MMP9 CLG4B; GELB; MANDP2; MMP-9 matrix metallopeptidase 9
TCMBANKGE001127 PRKAA1 AMPK; AMPKa1 protein kinase AMP-activated catalytic subunit alpha 1
TCMBANKGE001128 PRKAA2 AMPK; AMPK2; AMPKa2; PRKAA protein kinase AMP-activated catalytic subunit alpha 2
TCMBANKGE001132 BAX BCL2L4 BCL2 associated X, apoptosis regulator
TCMBANKGE001148 VEGFA MVCD1; VEGF; VPF vascular endothelial growth factor A
TCMBANKGE001154 CREB1 CREB; CREB-1 cAMP responsive element binding protein 1
TCMBANKGE001165 XIAP API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3 X-linked inhibitor of apoptosis
TCMBANKGE001166 BCL2 Bcl-2; PPP1R50 BCL2 apoptosis regulator
TCMBANKGE001169 BCL2L1 BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 BCL2 like 1
TCMBANKGE001198 BECN1 ATG6; VPS30; beclin1 beclin 1