Compound Summary

  Compound Information

TCMBANKIN059689

药名:	tripterine
分子式:	C29H38O4
Smiles:	CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
成分:	HBIN047148;HBIN020031
OB_score:	17.841444
CAS_id:	34157-83-0
SymMap_id:	SMIT05309;SMIT14614
TCMID_id:	23024;3368
TCMSP_id:	MOL003186
PubChem_id:	122724

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000885		东北雷公藤
TCMBANKHE002915	Crossopetalum gaumeri
TCMBANKHE003734	radix tripterygii wilfordii	雷公藤			To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage./Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen.
TCMBANKHE003842	Celastrus orbiculatus [Syn. Celastrus articulatus ]	南蛇藤根			To dispel wind and overcome damp, move qi and dissipate blood, resolve toxin and disperse swelling./Wind-damp impediment pain, painful swelling from knocks and falls, amenorrhea, headache, lumbago, mounting qi , dysentery, intestinal wind bleeding, swelling toxin of welling abscess and flat abscess, burns and scalds, poisonous snake bite.
TCMBANKHE003993		南蛇藤果			Palpitation and insomnia, amnesia and heavy dreams, toothache, pain in sinews and bones, numbness in lumbus and leg, painful wound from knocks and falls.
TCMBANKHE005098	Celastrus scandens	美洲南蛇藤
TCMBANKHE007049	Tripterygium regelii	黑曼			To dispel wind and eliminate damp, disinhibit water and disperse edema, resolve toxin and kill worms./Rheumatoid arthritis, jaundice, glomus accumulation, knocks and falls, scrofula, toxin swelling of sores, tinea capitis, itchy skin, poisonous snake bite.
TCMBANKHE007020	Celastrus strigillosus	粗毛南蛇藤
TCMBANKHE005716/YEM-243	Semen Canbis;Fructus Canbis;Fructus cannabis|Cannabis sativa L.	火麻仁;麻子仁|大麻	大麻	云南民族药物志：第二卷	To cause Taxation.;Purging by moisterizing/Blood and liquid depletion, intestinal dry and constipation.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE005898/YNS-113/YEM-98/XU-75	Tripterygium hypoglaucum|Tripterygium hypoglaucu (Lévl.) Hutch.|Tripterygium hypoglaucum (Lévl. )Lévl.ex ex Hutch.	昆明山海棠	火把花根|昆明山海棠	云南药材标准：第二册|云南民族药物志：第一卷|云南省保山市隆阳区瓦房乡	祛风除湿，舒经通络，消肿止痛。用于风寒湿痹，关节肿痛，跌倒损伤，红斑狼疮，皮痹瘙痒骨痨骨疽，睾丸结核|To dispel wind and eliminate damp, quicken blood and stanch bleeding, soothe sinews and joint bones, resolve toxin and kill worms./Rheumatic arthritis, wind-damp impediment pain, hemiplegia, mounting qi , dysmenorrhea, profuse menstruation, postpartum abdominal pain, incessant bleeding, acute infectious hepatitis, chronic nephritis, erythematous lupus, fracture, medullitis, bone tuberculosis, epididymis tubercle, sore toxin, psoriasis, neurodermatitis.	哈尼族/拉祜族/傈僳族/彝族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000008	Brain Neoplasms	group	Neoplasms; Nervous System Diseases	24810052
TCMBANKDI000009	Glioma	disease	Neoplasms	31735550
TCMBANKDI000026	Obesity	disease	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases	30821426
TCMBANKDI000031	Insulin Resistance	phenotype	Nutritional and Metabolic Diseases	28123944
TCMBANKDI000033	Non-alcoholic Fatty Liver Disease	disease	Digestive System Diseases	28123944
TCMBANKDI000054	Alzheimer's Disease	disease	Nervous System Diseases; Mental Disorders	24849358
TCMBANKDI000056	Heart failure	disease	Cardiovascular Diseases	29987023
TCMBANKDI000067	Head and Neck Neoplasms	group	Neoplasms	22641218
TCMBANKDI000070	Osteosarcoma	disease	Neoplasms	25611379
TCMBANKDI000085	Inflammation	phenotype	Pathological Conditions, Signs and Symptoms	29789558
TCMBANKDI000090	Acute kidney injury	disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	30268831
TCMBANKDI000094	Edema	phenotype	Pathological Conditions, Signs and Symptoms	27597642
TCMBANKDI005371	Retinal Degeneration	phenotype	Eye Diseases	26920853
TCMBANKDI007361	Multiple Myeloma	disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases	21506956
TCMBANKDI008221	Arthritis	disease	Musculoskeletal Diseases	31124139
TCMBANKDI008572	Rheumatoid Arthritis	disease	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases	31124139
TCMBANKDI011322	Gaucher Disease	disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases	24351928
TCMBANKDI011552	Kidney Diseases	group	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	29789558
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	22641218
TCMBANKDI013275	Brain Infarction	disease	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases	29540209
TCMBANKDI013888	Fibrosis	phenotype	Pathological Conditions, Signs and Symptoms	29789558
TCMBANKDI015496	Liver neoplasms	group	Digestive System Diseases; Neoplasms	24849358
TCMBANKDI015830	Myocardial Ischemia	disease	Cardiovascular Diseases	25041185
TCMBANKDI018012	Ureteral obstruction	phenotype	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	29789558
TCMBANKDI020247	Cardiomegaly	phenotype	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases	29987023
TCMBANKDI021229	Fatty Liver	disease	Digestive System Diseases	26344102
TCMBANKDI023555	Hypoxia	phenotype	Pathological Conditions, Signs and Symptoms	25041185
TCMBANKDI024649	Neuroblastoma	disease	Neoplasms	24849358
TCMBANKDI026275	Glioblastoma	disease	Neoplasms	24810052
TCMBANKDI027673	Arthritis, Experimental	disease	Musculoskeletal Diseases	22415021
TCMBANKDI030419	Hearing Loss	phenotype	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases	21866174
TCMBANKDI031985	Brain Ischemia	disease	Nervous System Diseases; Cardiovascular Diseases	29540209

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000168	NR3C1	GCCR; GCR; GCRST; GR; GRL	nuclear receptor subfamily 3 group C member 1
TCMBANKGE000257	FLT1	FLT; FLT-1; VEGFR-1; VEGFR1	fms related receptor tyrosine kinase 1
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000479	TIMP1	CLGI; EPA; EPO; HCI; TIMP; TIMP-1	TIMP metallopeptidase inhibitor 1
TCMBANKGE000810	BIRC2	API1; HIAP2; Hiap-2; MIHB; RNF48; c-IAP1; cIAP1	baculoviral IAP repeat containing 2
TCMBANKGE000820	CFLAR	CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; cFLIP	CASP8 and FADD like apoptosis regulator
TCMBANKGE000884	FN1	CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; SMDCF	fibronectin 1
TCMBANKGE000898	MYC	MRTL; MYCC; bHLHe39; c-Myc	MYC proto-oncogene, bHLH transcription factor
TCMBANKGE000979	KDR	CD309; FLK1; VEGFR; VEGFR2	kinase insert domain receptor
TCMBANKGE000994	AKR1B1	ADR; ALDR1; ALR2; AR	aldo-keto reductase family 1 member B
TCMBANKGE001013	BIRC5	API4; EPR-1	baculoviral IAP repeat containing 5
TCMBANKGE001037	MMP2	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1	matrix metallopeptidase 2
TCMBANKGE001045	CCND1	BCL1; D11S287E; PRAD1; U21B31	cyclin D1
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001118	MMP9	CLG4B; GELB; MANDP2; MMP-9	matrix metallopeptidase 9
TCMBANKGE001132	BAX	BCL2L4	BCL2 associated X, apoptosis regulator
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001167	CDC37	P50CDC37	cell division cycle 37, HSP90 cochaperone
TCMBANKGE001169	BCL2L1	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52	BCL2 like 1
TCMBANKGE001181	TGFB1	CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta	transforming growth factor beta 1
TCMBANKGE001697	MMP1	CLG; CLGN	matrix metallopeptidase 1
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE007151	TIMP2	CSC-21K; DDC8	TIMP metallopeptidase inhibitor 2
TCMBANKGE008278	COL4A4	ATS2; BFH; CA44	collagen type IV alpha 4 chain
TCMBANKGE009234	COL7A1	EBD1; EBDCT; EBR1; NDNC8	collagen type VII alpha 1 chain