Compound Summary

  Compound Information

TCMBANKIN061341

药名:	nuciferine
别名:	AC1MP6HA; Nuciferine; (R)-1,2-Dimethoxyaporphine; 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)-; AIDS189198; 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)- (9CI); l-5,6-Dimethoxyaporphine; AIDS-189198; 6a-beta-APORPHINE, 1,2-DIMETHOXY-; l-Nuciferine; Sanjoinine E; 475-83-2; (-)-Nucipherine; Nuciferin
分子式:	C19H21NO2
Smiles:	CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC
成分:	HBIN037568;HBIN037567
OB_score:	34.431029
CAS_id:	475-83-2
SymMap_id:	SMIT01542;SMIT08692
TCMID_id:	15847
TCMSP_id:	MOL007213
PubChem_id:	10146

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE002277		荷花
TCMBANKHE003028		粉萆薢			Treatment of chyluria, turbid urine mixed with whitish substance or whitish discharge from urethra, excessive leukorrhea, rheumatic arthralgia with limitation of motion and pain in the loins and knees.
TCMBANKHE004086	Plumula Nelumbinis	莲子心			To remove heat from the heart and calm the nerves, to restore the coordination between the heart and the kidney, to check emission, and to arrest bleeding./Heat entering pericardium, clouded spirit with delirious speech, non-interaction of heart and kidney, insomnia and emission, blood ejection due to blood heat, hypertension.
TCMBANKHE004636	Fructus Zizyphi Jujubae	大枣			To tonify the spleen and replenish qi, to nourish blood, and to ease the mind./Reduced food intake due to spleen vacuity, lack of strength and sloppy stool, visceral agitation.
TCMBANKHE004791	Herba Spirodelae	浮萍			To dispel wind-heat, to promote eruption, and to cause diuresis./Wind-heat exterior syndrome, non-eruption of measles, dormant papules with pruritus, edema, dribbling urinary block, sore and lichen, erysipelas, scalds.
TCMBANKHE008796	Avena sativa	燕麦
TCMBANKHE008144	Solanum aculeatissimum	丁茄			To suppress cough and calm asthma, dissipate stasis and relieve pain./Asthma, chronic bronchitis, stomachache, wind-damp pain, scrofula, cold suppurative sore, knocks and falls.
TCMBANKHE007734	Fructus Tribuli	蒺藜			To subdue hyperactivity of the liver, to promote blood circulation, to dispel wind, to clear the eye of opacity, and to arrest itching./1. Antitussive, expectorant and antiasthmatic. 2. Its alcoholic infusion exerts hypotensive effect in anesthetized animals.
TCMBANKHE008341	Fructus Zizyphi Jujubae	大枣			To tonify the spleen and replenish qi, to nourish blood, and to ease the mind./Reduced food intake due to spleen vacuity, lack of strength and sloppy stool, visceral agitation.
TCMBANKHE005111/YEM-104	Nelumbo nucifera|Nelumbo nucifera Gaertn.	荷叶蒂|莲	莲	云南民族药物志：第一卷	To clear summerheat and eliminate damp, dispel stasis and stanch bleeding, quiet fetus./Summerheat-damp diarrhea, blood dysentery, flooding and spotting, stirring fetus in pregnancy.	阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005257/YEM-104	Folium Nelumbinis|Nelumbo nucifera Gaertn.	荷叶|莲	莲	云南民族药物志：第一卷	To relieve summer-heat, to invigorate the spleen function of the spleen and arrest bleeding by reducing heat in blood./Summerheat-heat vexation and thirst, summerheat-damp diarrhea, spleen vacuity diarrhea, blood heat, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting.	阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE006652/YEM-104	Nelumbo nucifera|Nelumbo nucifera Gaertn.	莲子|莲	莲	云南民族药物志：第一卷	To supplement spleen and check diarrhea, boost kidney and secure essence, nourish heart and quiet spirit./Chronic diarrhea, inappetence, emission, restlessness, fright palpitation, insomnia, flooding and spotting, excessive leukorrhea.	阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000008	Brain Neoplasms	group	Neoplasms; Nervous System Diseases	30922391
TCMBANKDI000031	Insulin Resistance	phenotype	Nutritional and Metabolic Diseases	30129056
TCMBANKDI000081	Diabetes Mellitus, Experimental	disease	Nutritional and Metabolic Diseases; Endocrine System Diseases	30129056
TCMBANKDI013541	Vascular Diseases	group	Cardiovascular Diseases	25409881
TCMBANKDI013656	Glucose tolerance test	phenotype	-	30129056
TCMBANKDI021229	Fatty Liver	disease	Digestive System Diseases	30129056
TCMBANKDI026275	Glioblastoma	disease	Neoplasms	30922391

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000047	AKT1	AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA	AKT serine/threonine kinase 1
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000281	SNAI2	SLUG; SLUGH; SLUGH1; SNAIL2; WS2D	snail family transcriptional repressor 2
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000869	DRD2	D2DR; D2R	dopamine receptor D2
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE000965	CHRNA7	CHRNA7-2; NACHRA7	cholinergic receptor nicotinic alpha 7 subunit
TCMBANKGE000980	SOX2	ANOP3; MCOPS3	SRY-box transcription factor 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001107	NOS3	ECNOS; eNOS	nitric oxide synthase 3
TCMBANKGE001141	PPARA	NR1C1; PPAR; PPARalpha; hPPAR	peroxisome proliferator activated receptor alpha
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE008124	ADRA2B	ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; FAME2; alpha-2BAR	adrenoceptor alpha 2B
TCMBANKGE008700	CHRNA2	-	cholinergic receptor nicotinic alpha 2 subunit
TCMBANKGE008702	OPRM1	LMOR; M-OR-1; MOP; MOR; MOR1; OPRM	opioid receptor mu 1
TCMBANKGE008921	RXRA	NR2B1	retinoid X receptor alpha
TCMBANKGE009256	SLC6A2	NAT1; NET; NET1; SLC6A5	solute carrier family 6 member 2
TCMBANKGE009294	HTR3A	5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3	5-hydroxytryptamine receptor 3A
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE011923	CHRM4	HM4; M4R	cholinergic receptor muscarinic 4
TCMBANKGE012155	SLC6A3	DAT; DAT1; PKDYS; PKDYS1	solute carrier family 6 member 3
TCMBANKGE014050	GABRA1	ECA4; EIEE19; EJM; EJM5	gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014423	ADRA1A	ADRA1C; ADRA1L1; ALPHA1AAR	adrenoceptor alpha 1A
TCMBANKGE014625	OPRD1	DOP; DOR; DOR1; OPRD	opioid receptor delta 1