Compound Summary


  Compound Information

药名:

arctigenin

别名:

AIDS002466; C10545; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]tetrahydrofuran-2-one; arctigenin ; Arctigenin; 41328-87-4; MLS002473154; NCGC00025291-01; MEGxp0_001799; HMS2198I14; Arctigenin, (+)-; (3S,4S)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; 695QU32V04; SMR001397246; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxy-benzyl)tetrahydrofuran-2-one; 7770-78-7; 26687-78-5; (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone; AIDS-002466; ACon1_000416; Tocris-1777; (−)-Arctigenin; DTXSID50233381; UNII-2FD8L150E7 component NQWVSMVXKMHKTF-CVEARBPZSA-N; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone; (-)-Arctigenin; UNII-695QU32V04; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3S-trans)-; A1854_SIGMA; Arctigenen; 84413-77-4; Arctigenin, trans-(+)-; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]oxolan-2-one; (+)-Arctigenin; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3S,4S)-; ZINC899931; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-; CHEMBL369142; (-)-arctigenin

分子式:

C21H24O6

Smiles:

COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC

成分:

HBIN016609;HBIN016610

OB_score:

8.054341

CAS_id:

7770-78-7

SymMap_id:

SMIT00410

TCMID_id:

23018

TCMSP_id:

MOL000523

PubChem_id:

64981


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE002474 Saussurea laniceps 绵头雪莲花 To warm kidney and invigorate yang , regulate menstruation and stanch bleeding./Impotence, limp aching lumbus and knees, vaginal discharge, menstrual disorder, wind-damp impediment, bleeding due to external injury.
TCMBANKHE002499 Rhizoma Ahemones Daddeae 两头尖 To relieve rheumatic conditions, and to cure carbuncle./Treatment of rheumatoid arthritis with muscular contracture and joint pain, carbuncle with ulceration.
TCMBANKHE003265 牛蒡茎叶
TCMBANKHE003799 Fructus Forsythiae 连翘 To remove toxic heat, to cause subsidence of sweeling,and to eliminate modulation./Influenza in early stage, common cold in early stage, wind-heat common cold, encephalitis, hepatitis, tuberculosis, warm disease, heat strangury with inhibited pain, welling abscess, welling abscess and flat abscess, toxin swelling, scrofula, goiter and tuberculosis, throat impediment.
TCMBANKHE004000 Caulis Trachelospermi 络石藤 To dispel wind and remove obstruction from the channels and to remove heat from blood and cause subsidence of swelling./Wind-damp impediment pain, hypertonicity of sinews and vessels, aching in lumbus and knees, throat impediment, swollen welling abscess, knocks and falls.
TCMBANKHE004788 Saussurea involucrata; Saussurea tridactyla var. maidugonla 雪莲 To warm kidney and invigorate yang , dispel wind and overcome damp, quicken blood and free menstruation./Impotence, weakness in lumbus and knees, wind-damp impediment pain, menstrual disorder, amenorrhea, uterus cold and abdominal pain, cold rheum cough.
TCMBANKHE009004 Saussurea involucrata 雪莲 To warm kidney and invigorate yang , dispel wind and overcome damp, quicken blood and free menstruation./Impotence, weakness in lumbus and knees, wind-damp impediment pain, menstrual disorder, amenorrhea, uterus cold and abdominal pain, cold rheum cough.
TCMBANKHE009135/YNS-181/XU-60/XU-236 Arctium lappa|Arctium lappa L. 牛蒡根|牛蒡 牛蒡根 云南药材标准:第二册|西藏昌都市洛隆县 祛风清热,解毒消肿,力气通便。用于咽喉肿痛,牙龈肿痛,咳嗽痰稠,腹胀便秘,消渴;黄白带下,干血痨,产后少乳,风毒面肿,大头风,疮疡肿痛|To dispel wind-heat, disperse swelling toxin./Wind-heat common cold, headache, cough, wind toxin swollen face, swelling pain in th roat, gingiva painful swelling, wind-damp impediment pain, concretion and conglomeration, welling abscess and boil, hemorrhoids, prolapse of rectum.
TCMBANKHE006664/YNS-181/XU-60/XU-236 Fructus Arctii lappae|Arctium lappa L.|Arctium lappa 牛蒡子;大力子|牛蒡 牛蒡根 云南药材标准:第二册|西藏昌都市洛隆县 祛风清热,解毒消肿,力气通便。用于咽喉肿痛,牙龈肿痛,咳嗽痰稠,腹胀便秘,消渴;黄白带下,干血痨,产后少乳,风毒面肿,大头风,疮疡肿痛|To dispel wind-heat and relieve cough, to promote eruption, to counteract toxicity, and to soothe sore throat;Treament of cough and expectroation in influenza or upper respiratory infection, measles, rubella, sore throat, mumps, erysipelas, carbuncles and sores./Wind-heat common cold, cough with profuse phlegm, measles papules, wind papules, swelling pain in throat, epidemic parotitis;1. Its extract exerts a significant and prolonged effect of lowering blood sugar in rats.2. Mildly diuretic and laxative.3. An active component, arctiin, can induce tonic convulsion, feeble respiration and eventually paralysis in frogs, mice and rabbits. erysipelas, swollen welling abscess and sore toxin.
TCMBANKHE006892/YEM-215/XU-360 Wikstroemia indica|Wikstroemia indica (L.)C.A. Mey. 了哥王根|了哥王 了哥王 云南民族药物志:第二卷|广西崇左市天等县 To clear heat, disinhibit urine, resolve toxin, break accumulation and kill worms./Pertussis, rheumatic arthritis, leprosy, bronchial asthma, amebic dysentery, pneumonia, epidemic parotitis, edema, scrofula, toxin swelling of sores, swelling and pus of sores, knocks and falls. 傣族/德昂族/景颇族/傈僳族/苗族/瑶族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000089 Asthma disease Respiratory Tract Diseases; Immune System Diseases 26335809
TCMBANKDI015898 Glucose Metabolism Disorders group Nutritional and Metabolic Diseases 22095235

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000119 PDE4D ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4DN2; STRK1 phosphodiesterase 4D
TCMBANKGE000120 PDK1 - pyruvate dehydrogenase kinase 1
TCMBANKGE001112 PRKAB1 AMPK; HAMPKb protein kinase AMP-activated non-catalytic subunit beta 1
TCMBANKGE001127 PRKAA1 AMPK; AMPKa1 protein kinase AMP-activated catalytic subunit alpha 1
TCMBANKGE001128 PRKAA2 AMPK; AMPK2; AMPKa2; PRKAA protein kinase AMP-activated catalytic subunit alpha 2