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疾病ID:TCMBANKDI004922
疾病名:Frontotemporal Lobar Degeneration
MeSH_Name:Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
HPO_Name:-
UMLS_Name:Mental or Behavioral Dysfunction
DO_Name:-
疾病类型:disease
DisGeNET_Link:C0751072
MeSH_Link:C18; C10; F03
HPO_Link:-
UMLS_Link:T048
DO_Link:-
HERB_ID:-
疾病对应的植物
| ID | 拉丁名 | 药名 | 药用植物名 | 功能与主治 | 来源 | 药用部位 | 使用民族 |
|---|
疾病对应的化合物
| 化合物ID | 化合物名 | 别名 | 分子式 | 分子质量 | Smiles |
|---|
疾病对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000288 | ATF6 | ACHM7; ATF6A | activating transcription factor 6 |
| TCMBANKGE004944 | DCTN1 | DAP-150; DP-150; P135 | dynactin subunit 1 |
| TCMBANKGE010435 | COL17A1 | BA16H23.2; BP180; BPA-2; BPAG2; ERED; LAD-1 | collagen type XVII alpha 1 chain |
| TCMBANKGE004586 | CSE1L | CAS; CSE1; XPO2 | chromosome segregation 1 like |
| TCMBANKGE000562 | IL18 | IGIF; IL-18; IL-1g; IL1F4 | interleukin 18 |
| TCMBANKGE003298 | MFSD8 | CCMD; CLN7 | major facilitator superfamily domain containing 8 |
| TCMBANKGE005402 | CST3 | ARMD11; HEL-S-2 | cystatin C |
| TCMBANKGE002102 | RUNX1T1 | AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2 | RUNX1 partner transcriptional co-repressor 1 |
| TCMBANKGE000430 | LRRK2 | AURA17; DARDARIN; PARK8; RIPK7; ROCO2 | leucine rich repeat kinase 2 |
| TCMBANKGE005034 | BAG1 | BAG-1; HAP; RAP46 | BAG cochaperone 1 |
| TCMBANKGE000096 | TBK1 | FTDALS4; IIAE8; NAK; T2K | TANK binding kinase 1 |
| TCMBANKGE002926 | SNCG | BCSG1; SR | synuclein gamma |
| TCMBANKGE009968 | NPC2 | EDDM1; HE1 | NPC intracellular cholesterol transporter 2 |
| TCMBANKGE004616 | RBM45 | DRB1; RB-1 | RNA binding motif protein 45 |
| TCMBANKGE001076 | SOD2 | GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD | superoxide dismutase 2 |
| TCMBANKGE000010 | CDK5R1 | CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a | cyclin dependent kinase 5 regulatory subunit 1 |
| TCMBANKGE013383 | VCP | CDC48; TERA; p97 | valosin containing protein |
| TCMBANKGE014099 | CDC42 | CDC42Hs; G25K; TKS | cell division cycle 42 |
| TCMBANKGE007365 | IGFALS | ACLSD; ALS | insulin like growth factor binding protein acid labile subunit |
| TCMBANKGE002546 | PFN1 | ALS18 | profilin 1 |
| TCMBANKGE009975 | LAMC2 | B2T; BM600; CSF; EBR2; EBR2A; LAMB2T; LAMNB2 | laminin subunit gamma 2 |
| TCMBANKGE003296 | PHB2 | BAP; BCAP37; Bap37; PNAS-141; REA; hBAP; p22 | prohibitin 2 |
| TCMBANKGE007069 | STXBP3 | MUNC18-3; MUNC18C; PSP; UNC-18C | syntaxin binding protein 3 |
| TCMBANKGE000274 | CCL2 | GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF | C-C motif chemokine ligand 2 |
| TCMBANKGE000265 | SQSTM1 | A170; DMRV; FTDALS3; NADGP; OSIL; PDB3; ZIP3; p60; p62; p62B | sequestosome 1 |
| TCMBANKGE003444 | EWSR1 | EWS; EWS-FLI1; bK984G1.4 | EWS RNA binding protein 1 |
| TCMBANKGE000266 | DCTN4 | DYN4; P62 | dynactin subunit 4 |
| TCMBANKGE011747 | MATR3 | ALS21; MPD2; VCPDM | matrin 3 |
| TCMBANKGE001192 | HCRT | NRCLP1; OX; PPOX | hypocretin neuropeptide precursor |
| TCMBANKGE014747 | UNC119 | HRG4; IMD13; POC7; POC7A | unc-119 lipid binding chaperone |
| TCMBANKGE000031 | DNMT3A | DNMT3A2; HESJAS; M.HsaIIIA; TBRS | DNA methyltransferase 3 alpha |
| TCMBANKGE008888 | CHI3L1 | ASRT7; CGP-39; GP-39; GP39; HC-gp39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40; hCGP-39 | chitinase 3 like 1 |
| TCMBANKGE000028 | PHB | HEL-215; HEL-S-54e; PHB1 | prohibitin |
| TCMBANKGE000298 | SOD1 | ALS; ALS1; HEL-S-44; IPOA; SOD; STAHP; hSod1; homodimer | superoxide dismutase 1 |
| TCMBANKGE012155 | SLC6A3 | DAT; DAT1; PKDYS; PKDYS1 | solute carrier family 6 member 3 |
| TCMBANKGE000882 | SERPINE1 | PAI; PAI-1; PAI1; PLANH1 | serpin family E member 1 |
| TCMBANKGE010777 | DISC1 | C1orf136; SCZD9 | DISC1 scaffold protein |
| TCMBANKGE004842 | SRRM2 | 300-KD; CWF21; Cwc21; HSPC075; SRL300; SRm300 | serine/arginine repetitive matrix 2 |
| TCMBANKGE000032 | ARHGEF2 | GEF; GEF-H1; GEFH1; LFP40; Lfc; NEDMHM; P40 | Rho/Rac guanine nucleotide exchange factor 2 |
| TCMBANKGE014077 | PURA | MRD31; PUR-ALPHA; PUR1; PURALPHA | purine rich element binding protein A |
| TCMBANKGE000267 | GTF2H1 | BTF2; P62; TFB1; TFIIH | general transcription factor IIH subunit 1 |
| TCMBANKGE014931 | GFRA2 | GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2 | GDNF family receptor alpha 2 |
| TCMBANKGE001078 | XBP1 | TREB-5; TREB5; XBP-1; XBP2 | X-box binding protein 1 |
| TCMBANKGE000611 | CSF2 | CSF; GMCSF | colony stimulating factor 2 |
| TCMBANKGE001107 | NOS3 | ECNOS; eNOS | nitric oxide synthase 3 |
| TCMBANKGE004267 | REG1A | ICRF; P19; PSP; PSPS; PSPS1; PTP; REG | regenerating family member 1 alpha |
| TCMBANKGE000655 | Lamp2 | CD107b; LGP-B; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; Mac3 | lysosomal-associated membrane protein 2 |
| TCMBANKGE004155 | ZNF436 | ZNF; Zfp46 | zinc finger protein 436 |
| TCMBANKGE000194 | G3BP1 | G3BP; HDH-VIII | G3BP stress granule assembly factor 1 |
| TCMBANKGE000270 | KHDRBS1 | Sam68; p62; p68 | KH RNA binding domain containing, signal transduction associated 1 |
| TCMBANKGE009769 | RREB1 | FINB; HNT; LZ321; RREB-1; Zep-1 | ras responsive element binding protein 1 |
| TCMBANKGE000271 | APOE | AD2; APO-E; ApoE4; LDLCQ5; LPG | apolipoprotein E |
| TCMBANKGE008261 | PSAP | GLBA; SAP1; SAP2 | prosaposin |
| TCMBANKGE001126 | NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | nuclear factor, erythroid 2 like 2 |
| TCMBANKGE000535 | GGT1 | CD224; D22S672; D22S732; GGT; GGT 1; GGTD; GTG | gamma-glutamyltransferase 1 |
| TCMBANKGE000017 | MAPT | DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU | microtubule associated protein tau |
| TCMBANKGE006271 | TMED9 | GMP25; HSGP25L2G; p24a2; p24alpha2; p25 | transmembrane p24 trafficking protein 9 |
| TCMBANKGE012464 | GLS | AAD20; CASGID; EIEE71; GAC; GAM; GDPAG; GLS1; KGA | glutaminase |
| TCMBANKGE003553 | SNAP25 | CMS18; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SUP; bA416N4.2; dJ1068F16.2 | synaptosome associated protein 25 |
| TCMBANKGE002137 | PSEN1 | ACNINV3; AD3; FAD; PS-1; PS1; S182 | presenilin 1 |
| TCMBANKGE001581 | AKR1C4 | 3-alpha-HSD; C11; CDR; CHDR; DD-4; DD4; HAKRA | aldo-keto reductase family 1 member C4 |
| TCMBANKGE001152 | WNT2 | INT1L1; IRP | Wnt family member 2 |
| TCMBANKGE001646 | BLZF1 | GOLGIN-45; JEM-1; JEM-1s; JEM1 | basic leucine zipper nuclear factor 1 |
| TCMBANKGE002718 | ZNF763 | ZNF; ZNF440L | zinc finger protein 763 |
| TCMBANKGE000966 | SIGMAR1 | ALS16; DSMA2; OPRS1; SIG-1R; SR-BP; SR-BP1; SRBP; hSigmaR1; sigma1R | sigma non-opioid intracellular receptor 1 |
| TCMBANKGE004398 | CTCF | CFAP108; FAP108; MRD21 | CCCTC-binding factor |
| TCMBANKGE002600 | FUS | ALS6; ETM4; FUS1; HNRNPP2; POMP75; TLS | FUS RNA binding protein |
| TCMBANKGE004562 | CP | CP-2 | ceruloplasmin |
| TCMBANKGE004431 | WDR41 | MSTP048 | WD repeat domain 41 |
| TCMBANKGE008245 | SFPQ | POMP100; PPP1R140; PSF | splicing factor proline and glutamine rich |
| TCMBANKGE001158 | LEP | LEPD; OB; OBS | leptin |
| TCMBANKGE010713 | RAP1GAP | RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP | RAP1 GTPase activating protein |
| TCMBANKGE001046 | PIN1 | DOD; UBL5 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
| TCMBANKGE001176 | CAT | - | catalase |
| TCMBANKGE001579 | ZNF569 | ZAP1; ZNF; Zfp74 | zinc finger protein 569 |
| TCMBANKGE005092 | HNRNPA2B1 | HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1 | heterogeneous nuclear ribonucleoprotein A2/B1 |
| TCMBANKGE005615 | HNRNPA3 | 2610510D13Rik; D10S102; FBRNP; HNRPA3 | heterogeneous nuclear ribonucleoprotein A3 |
| TCMBANKGE002579 | RNF112 | BFP; ZNF179 | ring finger protein 112 |
| TCMBANKGE005810 | HTT | HD; IT15; LOMARS | huntingtin |
| TCMBANKGE010938 | SP4 | HF1B; SPR-1 | Sp4 transcription factor |
| TCMBANKGE000758 | HSF1 | HSTF1 | heat shock transcription factor 1 |
| TCMBANKGE000889 | HFE | HFE1; HH; HLA-H; MVCD7; TFQTL2 | homeostatic iron regulator |
| TCMBANKGE000059 | NGFR | CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR | nerve growth factor receptor |
| TCMBANKGE000823 | GABPA | E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07 | GA binding protein transcription factor subunit alpha |
| TCMBANKGE014391 | SUGP1 | F23858; RBP; SF4 | SURP and G-patch domain containing 1 |
| TCMBANKGE000934 | GFAP | ALXDRD | glial fibrillary acidic protein |
| TCMBANKGE013695 | PCBP2 | HNRNPE2; HNRPE2; hnRNP-E2 | poly(rC) binding protein 2 |
| TCMBANKGE002751 | TMEM106B | HLD16 | transmembrane protein 106B |
| TCMBANKGE000997 | GCG | GLP-1; GLP1; GLP2; GRPP | glucagon |
| TCMBANKGE013469 | FOXP2 | CAGH44; SPCH1; TNRC10 | forkhead box P2 |
| TCMBANKGE000835 | APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | amyloid beta precursor protein |
| TCMBANKGE008019 | INA | NEF5; NF-66; TXBP-1 | internexin neuronal intermediate filament protein alpha |
| TCMBANKGE015029 | TPPP | TPPP/p25; TPPP1; p24; p25; p25alpha | tubulin polymerization promoting protein |
| TCMBANKGE004238 | TTBK1 | BDTK | tau tubulin kinase 1 |
| TCMBANKGE000622 | SLPI | ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4 | secretory leukocyte peptidase inhibitor |
| TCMBANKGE014041 | LSM2 | C6orf28; G7B; YBL026W; snRNP | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| TCMBANKGE000690 | SYP | MRX96; MRXSYP | synaptophysin |
| TCMBANKGE010609 | UBQLN2 | ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2 | ubiquilin 2 |
| TCMBANKGE000926 | RRM2 | C2orf48; R2; RR2; RR2M | ribonucleotide reductase regulatory subunit M2 |
| TCMBANKGE000469 | CTSD | CLN10; CPSD; HEL-S-130P | cathepsin D |
| TCMBANKGE011952 | GGT2 | GGT; GGT 2 | gamma-glutamyltransferase 2 |
| TCMBANKGE000120 | PDK1 | - | pyruvate dehydrogenase kinase 1 |
| TCMBANKGE001515 | ADM | AM; PAMP | adrenomedullin |
| TCMBANKGE009633 | RAN | ARA24; Gsp1; TC4 | RAN, member RAS oncogene family |
| TCMBANKGE008444 | SLC2A4RG | GEF; HDBP-1; HDBP1; Si-1-2; Si-1-2-19 | SLC2A4 regulator |
| TCMBANKGE012517 | FLCN | BHD; DENND8B; FLCL | folliculin |
| TCMBANKGE012415 | PSEN2 | AD3L; AD4; CMD1V; PS2; STM2 | presenilin 2 |
| TCMBANKGE000287 | LAMP1 | CD107a; LAMPA; LGP120 | lysosomal associated membrane protein 1 |
| TCMBANKGE005322 | TIA1 | TIA-1; WDM | TIA1 cytotoxic granule associated RNA binding protein |
| TCMBANKGE000957 | MAP2K4 | JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1 | mitogen-activated protein kinase kinase 4 |
| TCMBANKGE005557 | LCN2 | 24p3; MSFI; NGAL; p25 | lipocalin 2 |
| TCMBANKGE012423 | PRNP | ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30 | prion protein |
| TCMBANKGE005018 | CDR1 | CDR; CDR34; CDR62A | cerebellar degeneration related protein 1 |
| TCMBANKGE007998 | TSPO | BPBS; BZRP; DBI; IBP; MBR; PBR; PBS; PKBS; PTBR; mDRC; pk18 | translocator protein |
| TCMBANKGE004326 | CDC7 | CDC7L1; HsCDC7; Hsk1; huCDC7 | cell division cycle 7 |
| TCMBANKGE001235 | NCL | C23; Nsr1 | nucleolin |
| TCMBANKGE005017 | HNRNPR | HNRPR; hnRNP-R | heterogeneous nuclear ribonucleoprotein R |
| TCMBANKGE015009 | SORT1 | Gp95; LDLCQ6; NT3; NTR3 | sortilin 1 |
| TCMBANKGE000300 | SLC1A3 | EA6; EAAT1; GLAST; GLAST1 | solute carrier family 1 member 3 |
| TCMBANKGE000276 | NOS1 | IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS | nitric oxide synthase 1 |
| TCMBANKGE000828 | TREM2 | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c | triggering receptor expressed on myeloid cells 2 |
| TCMBANKGE011954 | TARDBP | ALS10; TDP-43 | TAR DNA binding protein |
| TCMBANKGE000223 | KEAP1 | INrf2; KLHL19 | kelch like ECH associated protein 1 |
| TCMBANKGE008393 | GRN | CLN11; GEP; GP88; PCDGF; PEPI; PGRN | granulin precursor |
| TCMBANKGE009876 | HMBS | PBG-D; PBGD; PORC; UPS | hydroxymethylbilane synthase |
| TCMBANKGE000593 | PPA1 | HEL-S-66p; IOPPP; PP; PP1; SID6-8061 | inorganic pyrophosphatase 1 |
| TCMBANKGE006619 | DCUN1D1 | DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3 | defective in cullin neddylation 1 domain containing 1 |
| TCMBANKGE010787 | CHIT1 | CHI3; CHIT; CHITD | chitinase 1 |
| TCMBANKGE007225 | HNRNPA1 | ALS19; ALS20; HNRPA1; HNRPA1L3; IBMPFD3; UP 1; hnRNP A1; hnRNP-A1 | heterogeneous nuclear ribonucleoprotein A1 |
| TCMBANKGE011044 | ZNF629 | ZNF; ZNF65 | zinc finger protein 629 |
| TCMBANKGE001001 | SNCA | NACP; PARK1; PARK4; PD1 | synuclein alpha |
| TCMBANKGE003625 | SLC6A4 | 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT | solute carrier family 6 member 4 |
| TCMBANKGE007291 | UBE2V1 | CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A | ubiquitin conjugating enzyme E2 V1 |
| TCMBANKGE001071 | NPC1 | NPC; POGZ; SLC65A1 | NPC intracellular cholesterol transporter 1 |
| TCMBANKGE007452 | DST | BP240; BPA; BPAG1; CATX-15; CATX15; D6S1101; DMH; DT; EBSB2; HSAN6; MACF2 | dystonin |
| TCMBANKGE011840 | ZNF253 | BMZF-1; BMZF1; ZNF411 | zinc finger protein 253 |
| TCMBANKGE000236 | BDNF | ANON2; BULN2 | brain derived neurotrophic factor |
| TCMBANKGE002451 | PRMT8 | HRMT1L3; HRMT1L4 | protein arginine methyltransferase 8 |
| TCMBANKGE013109 | PSPH | PSP; PSPHD | phosphoserine phosphatase |
| TCMBANKGE004231 | GLE1 | CAAHC; CAAHD; GLE1L; LCCS; LCCS1; hGLE1 | GLE1 RNA export mediator |
| TCMBANKGE008023 | LBP | BPIFD2 | lipopolysaccharide binding protein |
| TCMBANKGE011881 | NPM1 | B23; NPM | nucleophosmin 1 |
| TCMBANKGE010103 | OPTN | ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP | optineurin |
| TCMBANKGE000548 | MFGE8 | BA46; EDIL1; HMFG; HsT19888; MFG-E8; MFGM; OAcGD3S; SED1; SPAG10; hP47 | milk fat globule EGF and factor V/VIII domain containing |
| TCMBANKGE007873 | VSNL1 | HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1 | visinin like 1 |
| TCMBANKGE001825 | CCL8 | HC14; MCP-2; MCP2; SCYA10; SCYA8 | C-C motif chemokine ligand 8 |
| TCMBANKGE007612 | SYNCRIP | GRY-RBP; GRYRBP; HNRNPQ; HNRPQ1; NSAP1; PP68; hnRNP-Q | synaptotagmin binding cytoplasmic RNA interacting protein |
| TCMBANKGE000268 | NUP62 | IBSN; SNDI; p62 | nucleoporin 62 |
| TCMBANKGE007674 | MAK16 | MAK16L; RBM13 | MAK16 homolog |
| TCMBANKGE006010 | RETN | ADSF; FIZZ3; RETN1; RSTN; XCP1 | resistin |
| TCMBANKGE010237 | BPIFA2 | C20orf70; PSP; SPLUNC2; bA49G10.1 | BPI fold containing family A member 2 |
| TCMBANKGE006511 | PTBP1 | HNRNP-I; HNRNPI; HNRPI; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; pPTB | polypyrimidine tract binding protein 1 |
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Dai SX Lab