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疾病ID:TCMBANKDI014359

疾病名:Craniofacial Abnormalities

MeSH_Name:Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases

HPO_Name:-

UMLS_Name:Congenital Abnormality

DO_Name:-

疾病类型:group

DisGeNET_Link:C0376634

MeSH_Link:C16; C05

HPO_Link:-

UMLS_Link:T019

DO_Link:-

HERB_ID:HBDIS008576

   疾病对应的植物
ID 拉丁名 药名 药用植物名 功能与主治 来源 药用部位 使用民族
   疾病对应的化合物
化合物ID 化合物名 别名 分子式 分子质量 Smiles
   疾病对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE009495 MASP1 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF mannan binding lectin serine peptidase 1
TCMBANKGE008144 PRKRA DYT16; HSD14; PACT; RAX protein activator of interferon induced protein kinase EIF2AK2
TCMBANKGE001033 FGFR1 BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD; bFGF-R-1 fibroblast growth factor receptor 1
TCMBANKGE001180 SMAD3 HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3 SMAD family member 3
TCMBANKGE008530 DLG1 DLGH1; SAP-97; SAP97; hdlg discs large MAGUK scaffold protein 1
TCMBANKGE010499 RYK D3S3195; JTK5; JTK5A; RYK1 receptor like tyrosine kinase
TCMBANKGE003295 GATA2 DCML; IMD21; MONOMAC; NFE1B GATA binding protein 2
TCMBANKGE003804 FGFR2 BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25 fibroblast growth factor receptor 2
TCMBANKGE009296 ESCO2 2410004I17Rik; EFO2; EFO2p; RBS; hEFO2 establishment of sister chromatid cohesion N-acetyltransferase 2
TCMBANKGE003957 TRPS1 GC79; LGCR transcriptional repressor GATA binding 1
TCMBANKGE014455 RAI1 SMCR; SMS retinoic acid induced 1
TCMBANKGE000711 SOX4 CSS10; EVI16 SRY-box transcription factor 4
TCMBANKGE014280 JAG1 AGS; AGS1; AHD; AWS; CD339; DCHE; HJ1; JAGL1 jagged canonical Notch ligand 1
TCMBANKGE008928 GLRA4 - glycine receptor alpha 4 (pseudogene)
TCMBANKGE008062 DLL3 SCDO1 delta like canonical Notch ligand 3
TCMBANKGE001104 TGFB2 G-TSF; LDS4; TGF-beta2 transforming growth factor beta 2
TCMBANKGE004990 RCAN1 ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1 regulator of calcineurin 1
TCMBANKGE002963 ALX1 CART1; FND3; HEL23 ALX homeobox 1
TCMBANKGE000660 DNMT3B ICF; ICF1; M.HsaIIIB DNA methyltransferase 3 beta
TCMBANKGE006904 MBTPS1 PCSK8; S1P; SEDKF; SKI-1 membrane bound transcription factor peptidase, site 1
TCMBANKGE008065 COL11A1 CO11A1; COLL6; DFNA37; STL2 collagen type XI alpha 1 chain
TCMBANKGE007917 IDUA IDA; MPS1; MPSI alpha-L-iduronidase
TCMBANKGE007713 LPAR1 EDG2; GPR26; Gpcr26; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1 lysophosphatidic acid receptor 1
TCMBANKGE007781 ZNF462 WSKA; ZFPIP; Zfp462 zinc finger protein 462
TCMBANKGE000897 GLI3 ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV GLI family zinc finger 3
TCMBANKGE009869 GNAQ CMC1; G-ALPHA-q; GAQ; SWS G protein subunit alpha q
TCMBANKGE012728 SH3PXD2B FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4 SH3 and PX domains 2B
TCMBANKGE008459 TMEM87B - transmembrane protein 87B
TCMBANKGE013807 ATP6AP2 APT6M8-9; ATP6IP2; ATP6M8-9; CDG2R; ELDF10; HT028; M8-9; MRXE; MRXSH; MSTP009; PRR; RENR; XMRE; XPDS ATPase H+ transporting accessory protein 2
TCMBANKGE010385 CNTN4 AXCAM; BIG-2 contactin 4
TCMBANKGE000162 MMP13 CLG3; MANDP1; MDST; MMP-13 matrix metallopeptidase 13
TCMBANKGE009857 THRB C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2 thyroid hormone receptor beta
TCMBANKGE013762 ERCC6 ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; POF11; RAD26; UVSS1 ERCC excision repair 6, chromatin remodeling factor
TCMBANKGE009966 ACAN AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK; SSOAOD aggrecan
TCMBANKGE008312 CKAP4 CLIMP-63; CLIMP63; ERGIC-63; p63 cytoskeleton associated protein 4
TCMBANKGE014985 PTH FIH1; PTH1 parathyroid hormone
TCMBANKGE004272 DVL2 - dishevelled segment polarity protein 2
TCMBANKGE000500 EPHX1 EPHX; EPOX; HYL1; MEH epoxide hydrolase 1
TCMBANKGE004881 SLC26A2 D5S1708; DTD; DTDST; EDM4; MST153; MSTP157 solute carrier family 26 member 2
TCMBANKGE007399 SATB2 GLSS SATB homeobox 2
TCMBANKGE004262 INTS1 INT1; NDCAGF; NET28 integrator complex subunit 1
TCMBANKGE001136 MECP2 AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT methyl-CpG binding protein 2
TCMBANKGE011404 CHD8 AUTS18; HELSNF1 chromodomain helicase DNA binding protein 8
TCMBANKGE013872 HSPG2 HSPG; PLC; PRCAN; SJA; SJS; SJS1 heparan sulfate proteoglycan 2
TCMBANKGE002341 FADD GIG3; MORT1 Fas associated via death domain
TCMBANKGE000697 APAF1 APAF-1; CED4 apoptotic peptidase activating factor 1
TCMBANKGE004848 CRY2 HCRY2; PHLL2 cryptochrome circadian regulator 2
TCMBANKGE003189 MMACHC cblC metabolism of cobalamin associated C
TCMBANKGE010653 FLI1 BDPLT21; EWSR2; SIC-1 Fli-1 proto-oncogene, ETS transcription factor
TCMBANKGE006700 B4GALT7 EDSP1; EDSSLA; EDSSPD1; XGALT1; XGPT; XGPT1 beta-1,4-galactosyltransferase 7
TCMBANKGE000031 DNMT3A DNMT3A2; HESJAS; M.HsaIIIA; TBRS DNA methyltransferase 3 alpha
TCMBANKGE004021 FMR1 FMRP; FRAXA; POF; POF1 FMRP translational regulator 1
TCMBANKGE000987 COL11A2 DFNA13; DFNB53; FBCG2; HKE5; OSMEDA; OSMEDB; PARP; STL3 collagen type XI alpha 2 chain
TCMBANKGE000206 FOXC2 FKHL14; LD; MFH-1; MFH1 forkhead box C2
TCMBANKGE012427 PAPPA ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1 pappalysin 1
TCMBANKGE004624 FZD4 CD344; EVR1; FEVR; FZD4S; Fz-4; Fz4; FzE4; GPCR; hFz4 frizzled class receptor 4
TCMBANKGE000166 EP300 KAT3B; MKHK2; RSTS2; p300 E1A binding protein p300
TCMBANKGE010925 ZIC3 HTX; HTX1; VACTERLX; ZNF203 Zic family member 3
TCMBANKGE000892 SP7 OI11; OI12; OSX; osterix Sp7 transcription factor
TCMBANKGE010034 ANKH ANK; CCAL2; CMDJ; CPPDD; HANK; MANK; SLC62A1 ANKH inorganic pyrophosphate transport regulator
TCMBANKGE013860 EDNRA ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR endothelin receptor type A
TCMBANKGE006629 SPRY2 IGAN3; hSPRY2 sprouty RTK signaling antagonist 2
TCMBANKGE007608 MNT MAD6; MXD6; ROX; bHLHd3; lncRNA-HAL MAX network transcriptional repressor
TCMBANKGE010320 BMPR1B ALK-6; ALK6; AMDD; BDA1D; BDA2; CDw293 bone morphogenetic protein receptor type 1B
TCMBANKGE000497 ETS2 ETS2IT1 ETS proto-oncogene 2, transcription factor
TCMBANKGE010606 HOXB1 HCFP3; HOX2; HOX2I; Hox-2.9 homeobox B1
TCMBANKGE001179 SMAD2 JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2 SMAD family member 2
TCMBANKGE001142 CHDH - choline dehydrogenase
TCMBANKGE007698 KIAA0586 JBTS23; SRTD14; Talpid3 KIAA0586
TCMBANKGE012462 RAX MCOP3; RX retina and anterior neural fold homeobox
TCMBANKGE011733 JAG2 HJ2; SER2 jagged canonical Notch ligand 2
TCMBANKGE000243 LMNA CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1 lamin A/C
TCMBANKGE001037 MMP2 CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1 matrix metallopeptidase 2
TCMBANKGE012418 GPC6 OMIMD1 glypican 6
TCMBANKGE006150 RAB40AL MRXSMP; RAR2; RLGP RAB40A like
TCMBANKGE000160 COL2A1 ANFH; AOM; COL11A3; SEDC; STL1 collagen type II alpha 1 chain
TCMBANKGE008498 TASP1 C20orf13; dJ585I14.2 taspase 1
TCMBANKGE011031 CYP2C9 CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9 cytochrome P450 family 2 subfamily C member 9
TCMBANKGE004648 SRP68 - signal recognition particle 68
TCMBANKGE006510 MSX2 CRS2; FPP; HOX8; MSH; PFM; PFM1 msh homeobox 2
TCMBANKGE008465 NIPBL CDLS; CDLS1; IDN3; IDN3-B; Scc2 NIPBL cohesin loading factor
TCMBANKGE003467 SLC35D1 SHNKND; UGTREL7 solute carrier family 35 member D1
TCMBANKGE000202 RUNX2 AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA RUNX family transcription factor 2
TCMBANKGE009402 KIF3A FLA10; KLP-20 kinesin family member 3A
TCMBANKGE013050 LETM1 SLC55A1 leucine zipper and EF-hand containing transmembrane protein 1
TCMBANKGE012480 DCHS1 CDH19; CDH25; CDHR6; FIB1; MVP2; PCDH16; VMLDS1 dachsous cadherin-related 1
TCMBANKGE000800 GABRB3 ECA5; EIEE43 gamma-aminobutyric acid type A receptor subunit beta3
TCMBANKGE002410 PITX2 ARP1; ASGD4; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PTX2; RGS; RIEG; RIEG1; RS paired like homeodomain 2
TCMBANKGE012841 HLA-A HLAA major histocompatibility complex, class I, A
TCMBANKGE004334 FBLN7 TM14 fibulin 7
TCMBANKGE003228 LRP2 DBS; GP330; LRP-2 LDL receptor related protein 2
TCMBANKGE012164 STRA6 MCOPCB8; MCOPS9; PP14296 signaling receptor and transporter of retinol STRA6
TCMBANKGE014789 TMEM165 CDG2K; FT27; GDT1; TMPT27; TPARL transmembrane protein 165
TCMBANKGE004101 RPE65 BCO3; LCA2; RP20; mRPE65; p63; rd12; sRPE65 retinoid isomerohydrolase RPE65
TCMBANKGE001524 SKI SGS; SKV SKI proto-oncogene
TCMBANKGE004168 SALL4 DRRS; HSAL4; ZNF797 spalt like transcription factor 4
TCMBANKGE001030 NOTCH1 AOS5; AOVD1; TAN1; hN1 notch receptor 1
TCMBANKGE011694 DLX2 TES-1; TES1 distal-less homeobox 2
TCMBANKGE001088 SMAD4 DPC4; JIP; MADH4; MYHRS SMAD family member 4
TCMBANKGE007467 FOXI1 FKH10; FKHL10; FREAC-6; FREAC6; HFH-3; HFH3 forkhead box I1
TCMBANKGE001322 CDKAL1 - CDK5 regulatory subunit associated protein 1 like 1
TCMBANKGE000222 EDN1 ARCND3; ET1; HDLCQ7; PPET1; QME endothelin 1
TCMBANKGE007851 DCPS ARS; DCS1; HINT-5; HINT5; HSL1; HSPC015 decapping enzyme, scavenger
TCMBANKGE001959 B3GAT3 GLCATI; JDSCD; glcUAT-I beta-1,3-glucuronyltransferase 3
TCMBANKGE001540 FOLR1 FBP; FOLR; FRalpha folate receptor alpha
TCMBANKGE005329 HOXA1 BSAS; HOX1; HOX1F homeobox A1
TCMBANKGE000158 RHOA ARH12; ARHA; EDFAOB; RHO12; RHOH12 ras homolog family member A
TCMBANKGE000904 PTCH1 BCNS; NBCCS; PTC; PTC1; PTCH patched 1
TCMBANKGE010779 MN1 CEBALID; MGCR; MGCR1; MGCR1-PEN; dJ353E16.2 MN1 proto-oncogene, transcriptional regulator
TCMBANKGE004041 SPECC1L CYTSA; GBBB2; OBLFC1; TBHS sperm antigen with calponin homology and coiled-coil domains 1 like
TCMBANKGE001199 PDGFRA CD140A; PDGFR-2; PDGFR2 platelet derived growth factor receptor alpha
TCMBANKGE002485 PHEX HPDR; HPDR1; HYP; HYP1; LXHR; PEX; XLH phosphate regulating endopeptidase homolog X-linked
TCMBANKGE012983 CSNK1A1 CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1; PRO2975 casein kinase 1 alpha 1
TCMBANKGE006609 RIT1 NS8; RIBB; RIT; ROC1 Ras like without CAAX 1
TCMBANKGE007816 UVRAG DHTX; VPS38; p63 UV radiation resistance associated
TCMBANKGE005541 GTF2IRD1 BEN; CREAM1; GTF3; MUSTRD1; RBAP2; WBS; WBSCR11; WBSCR12; hMusTRD1alpha1 GTF2I repeat domain containing 1
TCMBANKGE003766 FAM83H AI3; AI3A family with sequence similarity 83 member H
TCMBANKGE011987 TP63 AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L tumor protein p63
TCMBANKGE012602 GP1BB BDPLT1; BS; CD42C; GPIBB; GPIbbeta glycoprotein Ib platelet subunit beta
TCMBANKGE000886 SOX9 CMD1; CMPD1; SRA1; SRXX2; SRXY10 SRY-box transcription factor 9
TCMBANKGE013469 FOXP2 CAGH44; SPCH1; TNRC10 forkhead box P2
TCMBANKGE010784 SURF1 CMT4K SURF1 cytochrome c oxidase assembly factor
TCMBANKGE000109 ACTB BRWS1; PS1TP5BP1 actin beta
TCMBANKGE006981 SIN3A WITKOS SIN3 transcription regulator family member A
TCMBANKGE012781 SETD1B KMT2G; Set1B SET domain containing 1B, histone lysine methyltransferase
TCMBANKGE000407 DYRK1A DYRK; DYRK1; HP86; MNB; MNBH; MRD7 dual specificity tyrosine phosphorylation regulated kinase 1A
TCMBANKGE009877 GPC4 K-glypican; KPTS glypican 4
TCMBANKGE002584 CHD7 CRG; HH5; IS3; KAL5 chromodomain helicase DNA binding protein 7
TCMBANKGE000912 SHH HHG1; HLP3; HPE3; MCOPCB5; SMMCI; ShhNC; TPT; TPTPS sonic hedgehog signaling molecule
TCMBANKGE008153 GSC SAMS goosecoid homeobox
TCMBANKGE004968 FGF8 AIGF; FGF-8; HBGF-8; HH6; KAL6 fibroblast growth factor 8
TCMBANKGE009995 ACTG1 ACT; ACTG; DFNA20; DFNA26; HEL-176 actin gamma 1
TCMBANKGE007184 MSX1 ECTD3; HOX7; HYD1; STHAG1 msh homeobox 1
TCMBANKGE014557 ANXA1 ANX1; LPC1 annexin A1
TCMBANKGE004120 IRX5 HMMS; IRX-2a; IRXB2 iroquois homeobox 5
TCMBANKGE000865 TGFA TFGA transforming growth factor alpha
TCMBANKGE002696 ZIC5 - Zic family member 5
TCMBANKGE006436 PHF21A BHC80; BM-006; IDDBCS; NEDMS PHD finger protein 21A
TCMBANKGE014510 HOXA3 HOX1; HOX1E homeobox A3
TCMBANKGE007879 BMPR1A 10q23del; ACVRLK3; ALK3; CD292; SKR5 bone morphogenetic protein receptor type 1A
TCMBANKGE004357 RAD23B HHR23B; HR23B; P58 RAD23 homolog B, nucleotide excision repair protein
TCMBANKGE001050 PKD2 APKD2; PC2; PKD4; Pc-2; TRPP2 polycystin 2, transient receptor potential cation channel
TCMBANKGE000899 GLI2 CJS; HPE9; PHS2; THP1; THP2 GLI family zinc finger 2
TCMBANKGE011279 NRXN1 Hs.22998; PTHSL2; SCZD17 neurexin 1
TCMBANKGE002913 ETS1 ETS-1; EWSR2; c-ets-1; p54 ETS proto-oncogene 1, transcription factor
TCMBANKGE009921 DLX6 - distal-less homeobox 6
TCMBANKGE004779 KDM2B CXXC2; FBXL10; Fbl10; JHDM1B; PCCX2 lysine demethylase 2B
TCMBANKGE000180 TCF4 CDG2T; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4; bHLHb19 transcription factor 4
TCMBANKGE005304 RDH10 SDR16C4 retinol dehydrogenase 10
TCMBANKGE008567 TCOF1 MFD1; TCS; TCS1; treacle treacle ribosome biogenesis factor 1
TCMBANKGE011723 DHCR7 SLOS 7-dehydrocholesterol reductase
TCMBANKGE008908 NDST1 HSST; MRT46; NST1 N-deacetylase and N-sulfotransferase 1
TCMBANKGE001122 AXIN2 AXIL; ODCRCS axin 2
TCMBANKGE000244 ZMPSTE24 FACE-1; FACE1; HGPS; PRO1; STE24; Ste24p zinc metallopeptidase STE24
TCMBANKGE002478 TFAP2B AP-2B; AP2-B; PDA2 transcription factor AP-2 beta
TCMBANKGE007328 PAX6 AN; AN1; AN2; ASGD5; D11S812E; FVH1; MGDA; WAGR paired box 6
TCMBANKGE006218 ANKRD11 ANCO-1; ANCO1; LZ16; T13 ankyrin repeat domain 11
TCMBANKGE003452 UBE3A ANCR; AS; E6-AP; EPVE6AP; HPVE6A ubiquitin protein ligase E3A
TCMBANKGE002973 NFIA BRMUTD; CTF; NF-I/A; NF1-A; NFI-A; NFI-L nuclear factor I A
TCMBANKGE006028 ALX3 FND; FND1 ALX homeobox 3
TCMBANKGE005471 LINGO2 LERN3; LRRN6C leucine rich repeat and Ig domain containing 2
TCMBANKGE002310 SEC61A1 HNFJ4; HSEC61; SEC61; SEC61A SEC61 translocon subunit alpha 1
TCMBANKGE008679 EFNB1 CFND; CFNS; EFB1; EFL3; EPLG2; Elk-L; LERK2 ephrin B1
TCMBANKGE006509 CYP26B1 CYP26A2; P450RAI-2; P450RAI2; RHFCA cytochrome P450 family 26 subfamily B member 1
TCMBANKGE004824 EIF4A3 DDX48; Fal1; MUK34; NMP265; NUK34; RCPS; eIF-4A-III; eIF4A-III; eIF4AIII eukaryotic translation initiation factor 4A3
TCMBANKGE012196 ATRX JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX ATRX chromatin remodeler
TCMBANKGE005627 LTBP3 DASS; GPHYSD3; LTBP-3; LTBP2; STHAG6; pp6425 latent transforming growth factor beta binding protein 3
TCMBANKGE005788 HPD 4-HPPD; 4HPPD; GLOD3; HPPDASE; PPD 4-hydroxyphenylpyruvate dioxygenase
TCMBANKGE004203 TGFBR2 AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TBR-ii; TBRII; TGFR-2; TGFbeta-RII transforming growth factor beta receptor 2
TCMBANKGE001672 FGF3 HBGF-3; INT2 fibroblast growth factor 3
TCMBANKGE011463 COLEC11 3MC2; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1 collectin subfamily member 11
TCMBANKGE010881 UXS1 SDR6E1; UGD UDP-glucuronate decarboxylase 1
TCMBANKGE014757 IDH2 D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH isocitrate dehydrogenase (NADP(+)) 2
TCMBANKGE000411 IRF6 LPS; OFC6; PIT; PPS; PPS1; VWS; VWS1 interferon regulatory factor 6
TCMBANKGE011795 ALX4 CRS5; FND2 ALX homeobox 4
TCMBANKGE005857 Pax3 Pax-3; Sp; Splchl2; splotch paired box 3
TCMBANKGE000771 TWIST1 ACS3; BPES2; BPES3; CRS; CRS1; CSO; SCS; SWCOS; TWIST; bHLHa38 twist family bHLH transcription factor 1
TCMBANKGE001450 ECE1 ECE endothelin converting enzyme 1
TCMBANKGE012341 POLR1A A190; AFDCIN; RPA1; RPA194; RPO1-4; RPO14 RNA polymerase I subunit A
TCMBANKGE001226 MED13L MRFACD; PROSIT240; THRAP2; TRAP240L mediator complex subunit 13L
TCMBANKGE010293 SETBP1 MRD29; SEB SET binding protein 1
TCMBANKGE011543 HMGCS1 HMGCS 3-hydroxy-3-methylglutaryl-CoA synthase 1
TCMBANKGE010023 HCFC1 CFF; HCF; HCF-1; HCF1; HFC1; MRX3; PPP1R89; VCAF host cell factor C1
TCMBANKGE008404 HMX1 H6; NKX5-3 H6 family homeobox 1

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