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疾病ID:TCMBANKDI016439
疾病名:Motor Neuron Disease
MeSH_Name:Nervous System Diseases
HPO_Name:-
UMLS_Name:Disease or Syndrome
DO_Name:genetic disease; disease of anatomical entity
疾病类型:disease
DisGeNET_Link:C0085084
MeSH_Link:C10
HPO_Link:-
UMLS_Link:T047
DO_Link:DOID:630; DOID:7
HERB_ID:-
疾病对应的植物
| ID | 拉丁名 | 药名 | 药用植物名 | 功能与主治 | 来源 | 药用部位 | 使用民族 |
|---|
疾病对应的化合物
| 化合物ID | 化合物名 | 别名 | 分子式 | 分子质量 | Smiles |
|---|
疾病对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE002250 | GJD2 | CX36; GJA9 | gap junction protein delta 2 |
| TCMBANKGE005115 | FIG4 | ALS11; BTOP; CMT4J; KIAA0274; SAC3; YVS; dJ249I4.1 | FIG4 phosphoinositide 5-phosphatase |
| TCMBANKGE004944 | DCTN1 | DAP-150; DP-150; P135 | dynactin subunit 1 |
| TCMBANKGE000019 | RAB5A | RAB5 | RAB5A, member RAS oncogene family |
| TCMBANKGE010435 | COL17A1 | BA16H23.2; BP180; BPA-2; BPAG2; ERED; LAD-1 | collagen type XVII alpha 1 chain |
| TCMBANKGE002758 | HSPB8 | CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22 | heat shock protein family B (small) member 8 |
| TCMBANKGE013320 | HDAC6 | CPBHM; HD6; JM21; PPP1R90 | histone deacetylase 6 |
| TCMBANKGE012555 | IGHMBP2 | CATF1; CMT2S; HCSA; HMN6; SMARD1; SMUBP2; ZFAND7 | immunoglobulin mu DNA binding protein 2 |
| TCMBANKGE002442 | NT5E | CALJA; CD73; E5NT; NT; NT5; NTE; eN; eNT | 5'-nucleotidase ecto |
| TCMBANKGE000849 | HK2 | HKII; HXK2 | hexokinase 2 |
| TCMBANKGE006517 | SLC1A2 | EAAT2; EIEE41; GLT-1; HBGT | solute carrier family 1 member 2 |
| TCMBANKGE000430 | LRRK2 | AURA17; DARDARIN; PARK8; RIPK7; ROCO2 | leucine rich repeat kinase 2 |
| TCMBANKGE003689 | MFAP1 | AMP | microfibril associated protein 1 |
| TCMBANKGE005007 | UPK3B | P35; UP3B; UPIIIB | uroplakin 3B |
| TCMBANKGE005312 | GFRA1 | GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1 | GDNF family receptor alpha 1 |
| TCMBANKGE013844 | UBQLN1 | DA41; DSK2; PLIC-1; UBQN; XDRP1 | ubiquilin 1 |
| TCMBANKGE000096 | TBK1 | FTDALS4; IIAE8; NAK; T2K | TANK binding kinase 1 |
| TCMBANKGE012932 | GCHFR | GFRP; HsT16933; P35 | GTP cyclohydrolase I feedback regulator |
| TCMBANKGE000261 | INS | IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10; PNDM4 | insulin |
| TCMBANKGE002926 | SNCG | BCSG1; SR | synuclein gamma |
| TCMBANKGE001076 | SOD2 | GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD | superoxide dismutase 2 |
| TCMBANKGE006661 | PNPLA6 | BNHS; LNMS; NTE; NTEMND; OMCS; SPG39; iPLA2delta; sws | patatin like phospholipase domain containing 6 |
| TCMBANKGE000010 | CDK5R1 | CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a | cyclin dependent kinase 5 regulatory subunit 1 |
| TCMBANKGE013383 | VCP | CDC48; TERA; p97 | valosin containing protein |
| TCMBANKGE000363 | GEMIN2 | SIP1; SIP1-delta | gem nuclear organelle associated protein 2 |
| TCMBANKGE007365 | IGFALS | ACLSD; ALS | insulin like growth factor binding protein acid labile subunit |
| TCMBANKGE002546 | PFN1 | ALS18 | profilin 1 |
| TCMBANKGE004116 | PRDX3 | AOP-1; AOP1; HBC189; MER5; PRO1748; SP-22; prx-III | peroxiredoxin 3 |
| TCMBANKGE004460 | RASGRF1 | CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1 | Ras protein specific guanine nucleotide releasing factor 1 |
| TCMBANKGE003479 | NEFH | CMT2CC; NFH | neurofilament heavy |
| TCMBANKGE000265 | SQSTM1 | A170; DMRV; FTDALS3; NADGP; OSIL; PDB3; ZIP3; p60; p62; p62B | sequestosome 1 |
| TCMBANKGE008315 | SLC9A3R2 | E3KARP; NHE3RF2; NHERF-2; NHERF2; OCTS2; SIP-1; SIP1; TKA-1 | SLC9A3 regulator 2 |
| TCMBANKGE008499 | CAST | BS-17; PLACK | calpastatin |
| TCMBANKGE000266 | DCTN4 | DYN4; P62 | dynactin subunit 4 |
| TCMBANKGE006348 | PPP1R15A | GADD34 | protein phosphatase 1 regulatory subunit 15A |
| TCMBANKGE001061 | CDK5 | LIS7; PSSALRE | cyclin dependent kinase 5 |
| TCMBANKGE006891 | SLCO6A1 | CT48; GST; OATP-I; OATP6A1; OATPY | solute carrier organic anion transporter family member 6A1 |
| TCMBANKGE000298 | SOD1 | ALS; ALS1; HEL-S-44; IPOA; SOD; STAHP; hSod1; homodimer | superoxide dismutase 1 |
| TCMBANKGE010621 | AGTPBP1 | CCP1; CONDCA; NNA1 | ATP/GTP binding protein 1 |
| TCMBANKGE000606 | NRG1 | ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF | neuregulin 1 |
| TCMBANKGE000740 | NOX1 | GP91-2; MOX1; NOH-1; NOH1 | NADPH oxidase 1 |
| TCMBANKGE009157 | ATL1 | AD-FSP; FSP1; GBP3; HSN1D; SPG3; SPG3A; atlastin1 | atlastin GTPase 1 |
| TCMBANKGE000267 | GTF2H1 | BTF2; P62; TFB1; TFIIH | general transcription factor IIH subunit 1 |
| TCMBANKGE000364 | SMN1 | BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541; TDRD16A | survival of motor neuron 1, telomeric |
| TCMBANKGE009771 | GAP43 | B-50; GAP-43; PP46 | growth associated protein 43 |
| TCMBANKGE006914 | DCDC2 | DCDC2A; DFNB66; NPHP19; NSC; RU2; RU2S | doublecortin domain containing 2 |
| TCMBANKGE000033 | SOS1 | GF1; GGF1; GINGF; HGF; NS4; SOS-1 | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| TCMBANKGE002967 | AAAS | AAA; AAASb; ADRACALA; ADRACALIN; ALADIN; GL003 | aladin WD repeat nucleoporin |
| TCMBANKGE011056 | BSCL2 | GNG3LG; HMN5; PELD; SPG17 | BSCL2 lipid droplet biogenesis associated, seipin |
| TCMBANKGE006741 | EPHA4 | EK8; HEK8; SEK; TYRO1 | EPH receptor A4 |
| TCMBANKGE013565 | CHCHD10 | C22orf16; FTDALS2; IMMD; MIX17A; N27C7-4; SMAJ | coiled-coil-helix-coiled-coil-helix domain containing 10 |
| TCMBANKGE000270 | KHDRBS1 | Sam68; p62; p68 | KH RNA binding domain containing, signal transduction associated 1 |
| TCMBANKGE004297 | SCAF11 | CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP | SR-related CTD associated factor 11 |
| TCMBANKGE000271 | APOE | AD2; APO-E; ApoE4; LDLCQ5; LPG | apolipoprotein E |
| TCMBANKGE010225 | PABPC1 | PAB1; PABP; PABP1; PABPC2; PABPL1 | poly(A) binding protein cytoplasmic 1 |
| TCMBANKGE000127 | MFN2 | CMT2A; CMT2A2; CMT2A2A; CMT2A2B; CPRP1; HMSN6A; HSG; MARF | mitofusin 2 |
| TCMBANKGE010922 | RPS6 | S6 | ribosomal protein S6 |
| TCMBANKGE000017 | MAPT | DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU | microtubule associated protein tau |
| TCMBANKGE006271 | TMED9 | GMP25; HSGP25L2G; p24a2; p24alpha2; p25 | transmembrane p24 trafficking protein 9 |
| TCMBANKGE002137 | PSEN1 | ACNINV3; AD3; FAD; PS-1; PS1; S182 | presenilin 1 |
| TCMBANKGE010454 | NOP56 | NOL5A; SCA36 | NOP56 ribonucleoprotein |
| TCMBANKGE001178 | STAT3 | ADMIO; ADMIO1; APRF; HIES | signal transducer and activator of transcription 3 |
| TCMBANKGE000698 | TIGAR | C12orf5; FR2BP | TP53 induced glycolysis regulatory phosphatase |
| TCMBANKGE012841 | HLA-A | HLAA | major histocompatibility complex, class I, A |
| TCMBANKGE011935 | RRAD | RAD; RAD1; REM3 | RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
| TCMBANKGE001040 | AIF1 | AIF-1; IBA1; IRT-1; IRT1 | allograft inflammatory factor 1 |
| TCMBANKGE001182 | SIRT1 | SIR2; SIR2L1; SIR2alpha | sirtuin 1 |
| TCMBANKGE003770 | KIF1B | CMT2; CMT2A; CMT2A1; HMSNII; KLP; NBLST1 | kinesin family member 1B |
| TCMBANKGE005537 | NEK1 | ALS24; NY-REN-55; SRPS2; SRPS2A; SRTD6 | NIMA related kinase 1 |
| TCMBANKGE000280 | VIM | - | vimentin |
| TCMBANKGE009489 | ARHGEF28 | RGNEF; RIP2; p190RHOGEF | Rho guanine nucleotide exchange factor 28 |
| TCMBANKGE000170 | GLRX | GRX; GRX1 | glutaredoxin |
| TCMBANKGE000966 | SIGMAR1 | ALS16; DSMA2; OPRS1; SIG-1R; SR-BP; SR-BP1; SRBP; hSigmaR1; sigma1R | sigma non-opioid intracellular receptor 1 |
| TCMBANKGE004266 | AR | AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM | androgen receptor |
| TCMBANKGE005577 | SEMA3A | COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SEMAL; SemD; coll-1 | semaphorin 3A |
| TCMBANKGE000730 | HSPB2 | HSP27; Hs.78846; LOH11CR1K; MKBP | heat shock protein family B (small) member 2 |
| TCMBANKGE007368 | GSTP1 | DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI | glutathione S-transferase pi 1 |
| TCMBANKGE002600 | FUS | ALS6; ETM4; FUS1; HNRNPP2; POMP75; TLS | FUS RNA binding protein |
| TCMBANKGE011129 | GH1 | GH; GH-N; GHB5; GHN; IGHD1A; IGHD1B; IGHD2; hGH-N | growth hormone 1 |
| TCMBANKGE000221 | GRIA2 | GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B | glutamate ionotropic receptor AMPA type subunit 2 |
| TCMBANKGE007172 | RNASE1 | RAC1; RIB1; RNS1 | ribonuclease A family member 1, pancreatic |
| TCMBANKGE009899 | PLS1 | DFNA76 | plastin 1 |
| TCMBANKGE005851 | ALS2 | ALS2CR6; ALSJ; IAHSP; PLSJ | alsin Rho guanine nucleotide exchange factor ALS2 |
| TCMBANKGE000003 | ASAH1 | AC; ACDase; ASAH; PHP; PHP32; SMAPME | N-acylsphingosine amidohydrolase 1 |
| TCMBANKGE013458 | RHOT1 | ARHT1; MIRO-1; MIRO1 | ras homolog family member T1 |
| TCMBANKGE001046 | PIN1 | DOD; UBL5 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
| TCMBANKGE001176 | CAT | - | catalase |
| TCMBANKGE010393 | EXOSC3 | CGI-102; PCH1B; RRP40; Rrp40p; bA3J10.7; hRrp-40; p10 | exosome component 3 |
| TCMBANKGE005092 | HNRNPA2B1 | HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1 | heterogeneous nuclear ribonucleoprotein A2/B1 |
| TCMBANKGE014962 | COX8A | COX; COX8; COX8-2; COX8L; VIII; VIII-L | cytochrome c oxidase subunit 8A |
| TCMBANKGE005615 | HNRNPA3 | 2610510D13Rik; D10S102; FBRNP; HNRPA3 | heterogeneous nuclear ribonucleoprotein A3 |
| TCMBANKGE000766 | ACHE | ACEE; ARACHE; N-ACHE; YT | acetylcholinesterase (Cartwright blood group) |
| TCMBANKGE000935 | S100B | NEF; S100; S100-B; S100beta | S100 calcium binding protein B |
| TCMBANKGE011739 | CTF1 | CT-1; CT1 | cardiotrophin 1 |
| TCMBANKGE000934 | GFAP | ALXDRD | glial fibrillary acidic protein |
| TCMBANKGE002751 | TMEM106B | HLD16 | transmembrane protein 106B |
| TCMBANKGE000835 | APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | amyloid beta precursor protein |
| TCMBANKGE000109 | ACTB | BRWS1; PS1TP5BP1 | actin beta |
| TCMBANKGE003554 | NEFM | NEF3; NF-M; NFM | neurofilament medium |
| TCMBANKGE013488 | SYNE1 | 8B; AMCM; ARCA1; C6orf98; CPG2; EDMD4; KASH1; MYNE1; Nesp1; SCAR8; dJ45H2.2 | spectrin repeat containing nuclear envelope protein 1 |
| TCMBANKGE015029 | TPPP | TPPP/p25; TPPP1; p24; p25; p25alpha | tubulin polymerization promoting protein |
| TCMBANKGE006573 | UCHL1 | HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1 | ubiquitin C-terminal hydrolase L1 |
| TCMBANKGE006553 | PON1 | ESA; MVCD5; PON | paraoxonase 1 |
| TCMBANKGE006216 | SETX | ALS4; AOA2; SCAN2; SCAR1; Sen1; bA479K20.2 | senataxin |
| TCMBANKGE002516 | GSTK1 | GST; GST 13-13; GST13; GST13-13; GSTK1-1; hGSTK1 | glutathione S-transferase kappa 1 |
| TCMBANKGE001978 | GRM2 | GLUR2; GPRC1B; MGLUR2; mGlu2 | glutamate metabotropic receptor 2 |
| TCMBANKGE014041 | LSM2 | C6orf28; G7B; YBL026W; snRNP | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| TCMBANKGE000384 | AIFM1 | AIF; AUNX1; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8; SEMDHL | apoptosis inducing factor mitochondria associated 1 |
| TCMBANKGE010609 | UBQLN2 | ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2 | ubiquilin 2 |
| TCMBANKGE008650 | FKBP1A | FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE | FKBP prolyl isomerase 1A |
| TCMBANKGE014557 | ANXA1 | ANX1; LPC1 | annexin A1 |
| TCMBANKGE009633 | RAN | ARA24; Gsp1; TC4 | RAN, member RAS oncogene family |
| TCMBANKGE006003 | APRT | AMP; APRTD | adenine phosphoribosyltransferase |
| TCMBANKGE004986 | ANG | ALS9; HEL168; RAA1; RNASE4; RNASE5 | angiogenin |
| TCMBANKGE000988 | HGF | DFNB39; F-TCF; HGFB; HPTA; SF | hepatocyte growth factor |
| TCMBANKGE003852 | LY6E | RIG-E; RIGE; SCA-2; SCA2; TSA-1 | lymphocyte antigen 6 family member E |
| TCMBANKGE005322 | TIA1 | TIA-1; WDM | TIA1 cytotoxic granule associated RNA binding protein |
| TCMBANKGE000646 | DECR1 | DECR; NADPH; SDR18C1 | 2,4-dienoyl-CoA reductase 1 |
| TCMBANKGE002261 | SPAST | ADPSP; FSP2; SPG4 | spastin |
| TCMBANKGE001200 | STMN1 | C1orf215; LAP18; Lag; OP18; PP17; PP19; PR22; SMN | stathmin 1 |
| TCMBANKGE000807 | NAIP | BIRC1; NLRB1; psiNAIP | NLR family apoptosis inhibitory protein |
| TCMBANKGE010529 | PLEKHG5 | CMTRIC; DSMA4; GEF720; Syx; Tech | pleckstrin homology and RhoGEF domain containing G5 |
| TCMBANKGE001125 | IGF1 | IGF; IGF-I; IGFI; MGF | insulin like growth factor 1 |
| TCMBANKGE005557 | LCN2 | 24p3; MSFI; NGAL; p25 | lipocalin 2 |
| TCMBANKGE000365 | DDX20 | DP103; GEMIN3 | DEAD-box helicase 20 |
| TCMBANKGE002728 | CNTF | HCNTF | ciliary neurotrophic factor |
| TCMBANKGE010583 | SMN2 | BCD541; C-BCD541; GEMIN1; SMNC; TDRD16B | survival of motor neuron 2, centromeric |
| TCMBANKGE000504 | IL12A | CLMF; IL-12A; NFSK; NKSF1; P35 | interleukin 12A |
| TCMBANKGE001193 | GDNF | ATF; ATF1; ATF2; HFB1-GDNF; HSCR3 | glial cell derived neurotrophic factor |
| TCMBANKGE007310 | MNAT1 | CAP35; MAT1; RNF66; TFB3 | MNAT1 component of CDK activating kinase |
| TCMBANKGE004182 | CDCA5 | SORORIN | cell division cycle associated 5 |
| TCMBANKGE000300 | SLC1A3 | EA6; EAAT1; GLAST; GLAST1 | solute carrier family 1 member 3 |
| TCMBANKGE000669 | LAS1L | Las1; Las1-like; WTS; dJ475B7.2 | LAS1 like ribosome biogenesis factor |
| TCMBANKGE000828 | TREM2 | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c | triggering receptor expressed on myeloid cells 2 |
| TCMBANKGE011954 | TARDBP | ALS10; TDP-43 | TAR DNA binding protein |
| TCMBANKGE008393 | GRN | CLN11; GEP; GP88; PCDGF; PEPI; PGRN | granulin precursor |
| TCMBANKGE014814 | VPS54 | HCC8; PPP1R164; SLP-8p; VPS54L; WR; hVps54L | VPS54 subunit of GARP complex |
| TCMBANKGE008746 | ATP7A | DSMAX; MK; MNK; SMAX3 | ATPase copper transporting alpha |
| TCMBANKGE014293 | HEXB | ENC-1AS; HEL-248; HEL-S-111 | hexosaminidase subunit beta |
| TCMBANKGE013184 | HP | BP; HP2ALPHA2; HPA1S | haptoglobin |
| TCMBANKGE000382 | PARK7 | DJ-1; DJ1; GATD2; HEL-S-67p | Parkinsonism associated deglycase |
| TCMBANKGE001001 | SNCA | NACP; PARK1; PARK4; PD1 | synuclein alpha |
| TCMBANKGE012757 | GEMIN6 | - | gem nuclear organelle associated protein 6 |
| TCMBANKGE000797 | HSPB1 | CMT2F; HEL-S-102; HMN2B; HS.76067; HSP27; HSP28; Hsp25; SRP27 | heat shock protein family B (small) member 1 |
| TCMBANKGE007175 | FCN2 | EBP-37; FCNL; P35; ficolin-2 | ficolin 2 |
| TCMBANKGE000236 | BDNF | ANON2; BULN2 | brain derived neurotrophic factor |
| TCMBANKGE000295 | FOXO3 | AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A | forkhead box O3 |
| TCMBANKGE004231 | GLE1 | CAAHC; CAAHD; GLE1L; LCCS; LCCS1; hGLE1 | GLE1 RNA export mediator |
| TCMBANKGE007742 | HSPB3 | DHMN2C; HMN2C; HSPL27 | heat shock protein family B (small) member 3 |
| TCMBANKGE013956 | DYNC1H1 | CMT2O; DHC1; DHC1a; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL-3; SMALED1; p22 | dynein cytoplasmic 1 heavy chain 1 |
| TCMBANKGE007692 | GSTM1 | GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1 | glutathione S-transferase mu 1 |
| TCMBANKGE006733 | PVR | CD155; HVED; NECL5; Necl-5; PVS; TAGE4 | PVR cell adhesion molecule |
| TCMBANKGE005458 | MT3 | GIF; GIFB; GRIF; ZnMT3 | metallothionein 3 |
| TCMBANKGE010103 | OPTN | ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP | optineurin |
| TCMBANKGE000289 | EIF2AK3 | PEK; PERK; WRS | eukaryotic translation initiation factor 2 alpha kinase 3 |
| TCMBANKGE003721 | VRK1 | PCH1; PCH1A | VRK serine/threonine kinase 1 |
| TCMBANKGE012516 | DSP | DCWHKTA; DP | desmoplakin |
| TCMBANKGE000268 | NUP62 | IBSN; SNDI; p62 | nucleoporin 62 |
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Dai SX Lab