Compound Summary
Compound Information
药名: | triptolide |
别名: | PG 490; CT0223; Bio2_000315; AKOS015895128; KBio2_005451; BSPBio_001595; NCGC00163411-02; Triptolide; BCPP000033; Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, [3bR-(3b.alpha.,4a.alpha.,5aS*,6.beta.,6a.beta.,7a.beta.,7b.alpha.,8aS*,8b.beta.)]-; KBio3_000629; N1733; CHEBI:94966; SCHEMBL10028421; Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-; AC-6084; IDI1_034065; NCGC00163411-01; NSC163062; KBio2_002883; NSC 163062; Bio2_000795; Triptolid; HY-32735; BRD-A13122391-001-01-9; SMR000466307; MLS000759410; Triptolide (9CI); C09204; Triptolide, Tripterygium wilfordii; PG-490; ST51052768; KBio2_000315; Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, [3bR-(3b.alpha.,4a.alpha.,5aS*,6.beta.,6a.beta.,7a.beta.,7b.alpha.,8aS*,8b.beta.)]-; CS-0286; KBio3_000630; Triptolide, from Tripterygium wilfordii, >=98% (HPLC), solid; 38748-32-2; PG490; SMP1_000110; KBioGR_000315; TPL; NCI60_001223; KBioSS_000315 |
分子式: | C20H24O6 |
Smiles: | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
成分: | HBIN047173 |
OB_score: | 51.2885 |
CAS_id: | 38748-32-2 |
SymMap_id: | SMIT00526 |
TCMID_id: | 21995 |
TCMSP_id: | MOL003187 |
PubChem_id: | 107985 |
DrugBank_id: | DB12025 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE000515 | 紫槿皮 | |||||
| TCMBANKHE003734 | radix tripterygii wilfordii | 雷公藤 | To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage./Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen. | |||
| TCMBANKHE005716/YEM-243 | Semen Canbis;Fructus Canbis;Fructus cannabis|Cannabis sativa L. | 火麻仁;麻子仁|大麻 | 大麻 | 云南民族药物志：第二卷 | To cause Taxation.;Purging by moisterizing/Blood and liquid depletion, intestinal dry and constipation. | 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族 |
| TCMBANKHE005898/YNS-113/YEM-98/XU-75 | Tripterygium hypoglaucum|Tripterygium hypoglaucu (Lévl.) Hutch.|Tripterygium hypoglaucum (Lévl. )Lévl.ex ex Hutch. | 昆明山海棠 | 火把花根|昆明山海棠 | 云南药材标准：第二册|云南民族药物志：第一卷|云南省保山市隆阳区瓦房乡 | 祛风除湿，舒经通络，消肿止痛。用于风寒湿痹，关节肿痛，跌倒损伤，红斑狼疮，皮痹瘙痒骨痨骨疽，睾丸结核|To dispel wind and eliminate damp, quicken blood and stanch bleeding, soothe sinews and joint bones, resolve toxin and kill worms./Rheumatic arthritis, wind-damp impediment pain, hemiplegia, mounting qi , dysmenorrhea, profuse menstruation, postpartum abdominal pain, incessant bleeding, acute infectious hepatitis, chronic nephritis, erythematous lupus, fracture, medullitis, bone tuberculosis, epididymis tubercle, sore toxin, psoriasis, neurodermatitis. | 哈尼族/拉祜族/傈僳族/彝族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI000002 | Hyperalgesia | phenotype | Pathological Conditions, Signs and Symptoms; Nervous System Diseases | 28300618 |
| TCMBANKDI000003 | Encephalitis | disease | Nervous System Diseases | 28300618 |
| TCMBANKDI000004 | Chronic pain | phenotype | Pathological Conditions, Signs and Symptoms | 28300618 |
| TCMBANKDI000006 | Nasopharyngeal Neoplasms | group | Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases | 30111354 |
| TCMBANKDI000007 | melanoma | disease | Neoplasms | 28740548 |
| TCMBANKDI000018 | Pancreatic Neoplasm | disease | Digestive System Diseases; Neoplasms; Endocrine System Diseases | 27919787 |
| TCMBANKDI000022 | Prostatic Neoplasms | group | Neoplasms; Male Urogenital Diseases | 28638477 |
| TCMBANKDI000029 | Body Weight | phenotype | Pathological Conditions, Signs and Symptoms | 22220673 |
| TCMBANKDI000048 | Neoplasms | group | Neoplasms | 23985699 |
| TCMBANKDI000053 | leukemia | disease | Neoplasms | 24309935 |
| TCMBANKDI000069 | Bone neoplasms | group | Neoplasms; Musculoskeletal Diseases | 29096654 |
| TCMBANKDI000070 | Osteosarcoma | disease | Neoplasms | 23499892 |
| TCMBANKDI000081 | Diabetes Mellitus, Experimental | disease | Nutritional and Metabolic Diseases; Endocrine System Diseases | 30741721 |
| TCMBANKDI000082 | Nasopharyngeal carcinoma | disease | Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases | 30111354 |
| TCMBANKDI000085 | Inflammation | phenotype | Pathological Conditions, Signs and Symptoms | 29178433 |
| TCMBANKDI000086 | Colonic Neoplasms | group | Digestive System Diseases; Neoplasms | 23758884 |
| TCMBANKDI000087 | Neoplasm Recurrence, Local | phenotype | Pathological Conditions, Signs and Symptoms; Neoplasms | 28951456 |
| TCMBANKDI000088 | Lung Neoplasms | group | Neoplasms; Respiratory Tract Diseases | 23499892 |
| TCMBANKDI001995 | Spinal Muscular Atrophy | disease | Nervous System Diseases | 22220673 |
| TCMBANKDI002163 | Neoplasms, Experimental | phenotype | Neoplasms | 23985699 |
| TCMBANKDI006012 | Neuralgia | phenotype | Pathological Conditions, Signs and Symptoms; Nervous System Diseases | 22901764 |
| TCMBANKDI006482 | Cancer Pain | phenotype | Pathological Conditions, Signs and Symptoms | 29096654 |
| TCMBANKDI006869 | Necrosis | phenotype | Pathological Conditions, Signs and Symptoms | 28740548 |
| TCMBANKDI008572 | Rheumatoid Arthritis | disease | Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases | 26713272 |
| TCMBANKDI013578 | Diabetic Cardiomyopathies | disease | Endocrine System Diseases; Cardiovascular Diseases | 23530831 |
| TCMBANKDI015496 | Liver neoplasms | group | Digestive System Diseases; Neoplasms | 29523159 |
| TCMBANKDI015740 | Colorectal Neoplasms | group | Digestive System Diseases; Neoplasms | 31122284 |
| TCMBANKDI017409 | Neurodegenerative Disorders | group | Nervous System Diseases | 25880276 |
| TCMBANKDI018904 | Carcinoma, Pancreatic Ductal | disease | Digestive System Diseases; Neoplasms; Endocrine System Diseases | 27384421 |
| TCMBANKDI019879 | Pancreatic Ductal Adenocarcinoma | disease | Digestive System Diseases; Neoplasms; Endocrine System Diseases | 27384421 |
| TCMBANKDI021016 | Graft Rejection | phenotype | - | 29178433 |
| TCMBANKDI021322 | Metastatic castration-resistant prostate cancer | disease | - | 28638477 |
| TCMBANKDI022691 | Triple Negative Breast Neoplasms | disease | Neoplasms; Skin and Connective Tissue Diseases | 28951456 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000047 | AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | AKT serine/threonine kinase 1 |
| TCMBANKGE000051 | IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | interleukin 1 beta |
| TCMBANKGE000052 | TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | tumor necrosis factor |
| TCMBANKGE000053 | NFKB1 | CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB | nuclear factor kappa B subunit 1 |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000238 | IL10 | CSIF; GVHDS; IL-10; IL10A; TGIF | interleukin 10 |
| TCMBANKGE000241 | CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | caspase 8 |
| TCMBANKGE000294 | CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | cyclin dependent kinase inhibitor 1A |
| TCMBANKGE000361 | ERCC2 | COFS2; EM9; TFIIH; TTD; TTD1; XPD | ERCC excision repair 2, TFIIH core complex helicase subunit |
| TCMBANKGE000362 | DNAH8 | ATPase; hdhc9 | dynein axonemal heavy chain 8 |
| TCMBANKGE000363 | GEMIN2 | SIP1; SIP1-delta | gem nuclear organelle associated protein 2 |
| TCMBANKGE000364 | SMN1 | BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541; TDRD16A | survival of motor neuron 1, telomeric |
| TCMBANKGE000365 | DDX20 | DP103; GEMIN3 | DEAD-box helicase 20 |
| TCMBANKGE000366 | DUSP6 | HH19; MKP3; PYST1 | dual specificity phosphatase 6 |
| TCMBANKGE000367 | POLR2A | NEDHIB; POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1 | RNA polymerase II subunit A |
| TCMBANKGE000368 | PLAUR | CD87; U-PAR; UPAR; URKR | plasminogen activator, urokinase receptor |
| TCMBANKGE000369 | IFNA1 | IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA13; IFNA@; leIF D | interferon alpha 1 |
| TCMBANKGE000370 | MIR204 | MIRN204; RDICC; miRNA204; mir-204 | microRNA 204 |
| TCMBANKGE000371 | MLC1 | LVM; MLC; VL | modulator of VRAC current 1 |
| TCMBANKGE000433 | IL37 | FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-37; IL1F7; IL1H4; IL1RP1 | interleukin 37 |
| TCMBANKGE000434 | PTGER2 | EP2 | prostaglandin E receptor 2 |
| TCMBANKGE000435 | PROM1 | AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4 | prominin 1 |
| TCMBANKGE000436 | ERBB4 | ALS19; HER4; p180erbB4 | erb-b2 receptor tyrosine kinase 4 |
| TCMBANKGE000437 | FZD1 | - | frizzled class receptor 1 |
| TCMBANKGE000438 | LRP6 | ADCAD2; STHAG7 | LDL receptor related protein 6 |
| TCMBANKGE000439 | CDK7 | CAK; CAK1; CDKN7; HCAK; MO15; STK1; p39MO15 | cyclin dependent kinase 7 |
| TCMBANKGE000440 | HDAC1 | GON-10; HD1; KDAC1; RPD3; RPD3L1 | histone deacetylase 1 |
| TCMBANKGE000441 | ERCC3 | BTF2; GTF2H; RAD25; TFIIH; TTD2; XPB | ERCC excision repair 3, TFIIH core complex helicase subunit |
| TCMBANKGE000442 | ZFP36L1 | BRF1; Berg36; ERF-1; ERF1; RNF162B; TIS11B; cMG1 | ZFP36 ring finger protein like 1 |
| TCMBANKGE000443 | TBP | GTF2D; GTF2D1; HDL4; SCA17; TFIID | TATA-box binding protein |
| TCMBANKGE000585 | BCL2L11 | BAM; BIM; BOD | BCL2 like 11 |
| TCMBANKGE000632 | ROCK1 | P160ROCK; ROCK-I | Rho associated coiled-coil containing protein kinase 1 |
| TCMBANKGE000661 | HDAC2 | HD2; KDAC2; RPD3; YAF1 | histone deacetylase 2 |
| TCMBANKGE000771 | TWIST1 | ACS3; BPES2; BPES3; CRS; CRS1; CSO; SCS; SWCOS; TWIST; bHLHa38 | twist family bHLH transcription factor 1 |
| TCMBANKGE000791 | DUSP1 | CL100; HVH1; MKP-1; MKP1; PTPN10 | dual specificity phosphatase 1 |
| TCMBANKGE000820 | CFLAR | CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; cFLIP | CASP8 and FADD like apoptosis regulator |
| TCMBANKGE000877 | ABCG2 | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1 | ATP binding cassette subfamily G member 2 (Junior blood group) |
| TCMBANKGE000898 | MYC | MRTL; MYCC; bHLHe39; c-Myc | MYC proto-oncogene, bHLH transcription factor |
| TCMBANKGE000968 | CYCS | CYC; HCS; THC4 | cytochrome c, somatic |
| TCMBANKGE000979 | KDR | CD309; FLK1; VEGFR; VEGFR2 | kinase insert domain receptor |
| TCMBANKGE000994 | AKR1B1 | ADR; ALDR1; ALR2; AR | aldo-keto reductase family 1 member B |
| TCMBANKGE001011 | TNFSF10 | APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL | TNF superfamily member 10 |
| TCMBANKGE001013 | BIRC5 | API4; EPR-1 | baculoviral IAP repeat containing 5 |
| TCMBANKGE001060 | YAP1 | COB1; YAP; YAP2; YAP65; YKI | Yes1 associated transcriptional regulator |
| TCMBANKGE001089 | PARP1 | ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1 | poly(ADP-ribose) polymerase 1 |
| TCMBANKGE001097 | HIF1A | HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78 | hypoxia inducible factor 1 subunit alpha |
| TCMBANKGE001106 | MTOR | FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS | mechanistic target of rapamycin kinase |
| TCMBANKGE001114 | IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | interleukin 6 |
| TCMBANKGE001117 | PTEN | 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; TEP1 | phosphatase and tensin homolog |
| TCMBANKGE001123 | CTNNB1 | CTNNB; EVR7; MRD19; NEDSDV; armadillo | catenin beta 1 |
| TCMBANKGE001124 | WNT1 | BMND16; INT1; OI15 | Wnt family member 1 |
| TCMBANKGE001126 | NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | nuclear factor, erythroid 2 like 2 |
| TCMBANKGE001131 | CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | caspase 9 |
| TCMBANKGE001146 | SNAI1 | SLUGH2; SNA; SNAH; SNAIL; SNAIL1; dJ710H13.1 | snail family transcriptional repressor 1 |
| TCMBANKGE001148 | VEGFA | MVCD1; VEGF; VPF | vascular endothelial growth factor A |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001165 | XIAP | API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3 | X-linked inhibitor of apoptosis |
| TCMBANKGE001173 | MCL1 | BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT | MCL1 apoptosis regulator, BCL2 family member |
| TCMBANKGE001184 | RELA | CMCU; NFKB3; p65 | RELA proto-oncogene, NF-kB subunit |
| TCMBANKGE001201 | MAPK3 | ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK | mitogen-activated protein kinase 3 |
| TCMBANKGE001202 | MAPK14 | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA | mitogen-activated protein kinase 14 |
| TCMBANKGE001203 | MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | mitogen-activated protein kinase 1 |
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