Compound Summary

  Compound Information

TCMBANKIN057931

药名:	DMR
别名:	CHEBI:30796; 02300_FLUKA; Malic acid, L(+)-; L(+)-Malic acid; C00497; InChI=1/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9; butanedioic acid, 2-hydroxy-; (R)-()-2-Hydroxysuccinic acid; (2R)-2-hydroxysuccinic acid; D-()-Malic acid; D-Hydroxybutanedioic acid; EINECS 211-262-2; (R)-malic acid; Malic acid D-(+)-form; 2-HYDROXY-SUCCINIC ACID; MLS000069520; (2R)-2-hydroxybutanedioic acid; 46940U_SUPELCO; SMR000058580; (+)-D-malic acid; Malic acid, D-; R-malic acid; D- malic acid
分子式:	C4H6O5
Smiles:	C(C(C(=O)O)O)C(=O)O
成分:	HBIN024339; HBIN042340; HBIN024322
OB_score:	68.624627
CAS_id:	97-67-6
SymMap_id:	SMIT04568
TCMID_id:	38102; 40678
TCMSP_id:	MOL002299
PubChem_id:	92824

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE003741	Vinegar	醋			To stanch bleeding and dissipate stasis, resolve toxin and kill worms./Postpartum blood dizziness, concretion and conglomeration, jaundice, yellow sweating, blood ejection, spontaneous external bleeding, hematochezia, itching in genital region, swelling of welling abscess, welling abscess and flat abscess with swelling sore.
TCMBANKHE004121	Radix Stemoe	百部			1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie.
TCMBANKHE004699	fructus hippophae	沙棘
TCMBANKHE006313	Radix et Rhizoma Rhei	大黄			To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE007363/YEM-744/XU-850	Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum	大黄; 生锦纹; 生军|掌叶大黄	掌叶大黄	云南民族药物志：第四卷|西藏昌都地区芒康县	To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect.	阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000278	METAP2	MAP2; MNPEP; p67eIF2	methionyl aminopeptidase 2
TCMBANKGE000328	PTPN11	BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2	protein tyrosine phosphatase non-receptor type 11
TCMBANKGE000359	MDH2	EIEE51; M-MDH; MDH; MGC:3559; MOR1	malate dehydrogenase 2
TCMBANKGE000469	CTSD	CLN10; CPSD; HEL-S-130P	cathepsin D
TCMBANKGE000727	MAP1LC3A	ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3	microtubule associated protein 1 light chain 3 alpha
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000830	GOT2	KAT4; KATIV; KYAT4; mitAAT	glutamic-oxaloacetic transaminase 2
TCMBANKGE000994	AKR1B1	ADR; ALDR1; ALR2; AR	aldo-keto reductase family 1 member B
TCMBANKGE001105	CS	-	citrate synthase
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001171	SRC	ASV; SRC1; THC6; c-SRC; p60-Src	SRC proto-oncogene, non-receptor tyrosine kinase
TCMBANKGE001347	LYPLAL1	Q96AV0	lysophospholipase like 1
TCMBANKGE001439	METAP1	MAP1A; MetAP1A	methionyl aminopeptidase 1
TCMBANKGE001691	GYS1	GSY; GYS	glycogen synthase 1
TCMBANKGE001795	PTPRG	HPTPG; PTPG; R-PTP-GAMMA; RPTPG	protein tyrosine phosphatase receptor type G
TCMBANKGE001890	ME2	ODS1	malic enzyme 2
TCMBANKGE002064	ECI1	DCI	enoyl-CoA delta isomerase 1
TCMBANKGE002771	METAP1D	MAP 1D; MAP1D; MetAP 1D; Metap1l	methionyl aminopeptidase type 1D, mitochondrial
TCMBANKGE003118	CA6	CA-VI; GUSTIN	carbonic anhydrase 6
TCMBANKGE003412	CDY2A	CDY; CDY2	chromodomain Y-linked 2A
TCMBANKGE003709	ALG2	CDG1I; CDGIi; CMS14; CMSTA3; NET38; hALPG2	ALG2 alpha-1,3/1,6-mannosyltransferase
TCMBANKGE004298	ATOX1	ATX1; HAH1	antioxidant 1 copper chaperone
TCMBANKGE004450	CA4	CAIV; Car4; RP17	carbonic anhydrase 4
TCMBANKGE004571	ACCS	ACS; PHACS	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)
TCMBANKGE004614	ASPH	AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin	aspartate beta-hydroxylase
TCMBANKGE004664	CDY1	CDY; CDY1A	chromodomain Y-linked 1
TCMBANKGE004756	GYS2	-	glycogen synthase 2
TCMBANKGE004923	CA3	CAIII; Car3	carbonic anhydrase 3
TCMBANKGE005209	PHGDH	3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA	phosphoglycerate dehydrogenase
TCMBANKGE005259	GPT2	ALT2; GPT 2; MRT49	glutamic--pyruvic transaminase 2
TCMBANKGE005762	ACACB	ACC2; ACCB; HACC275	acetyl-CoA carboxylase beta
TCMBANKGE006193	CA12	CA-XII; CAXII; HsT18816; T18816	carbonic anhydrase 12
TCMBANKGE006281	ALG1L	ALG1L1	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like
TCMBANKGE006333	CA5A	CA5; CA5AD; CAV; CAVA; GS1-21A4.1	carbonic anhydrase 5A
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE006362	DUSP23	DUSP25; LDP-3; LDP3; MOSP; VHZ	dual specificity phosphatase 23
TCMBANKGE006460	NPL	C112; C1orf13; NAL; NPL1	N-acetylneuraminate pyruvate lyase
TCMBANKGE006950	CA14	CAXiV	carbonic anhydrase 14
TCMBANKGE006951	PA2G4	EBP1; HG4-1; p38-2G4	proliferation-associated 2G4
TCMBANKGE007911	HADHA	ECHA; GBP; HADH; LCEH; LCHAD; MTPA; TP-ALPHA	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
TCMBANKGE007956	AUH	-	AU RNA binding methylglutaconyl-CoA hydratase
TCMBANKGE008007	CA10	CA-RPX; CARPX; HUCEP-15	carbonic anhydrase 10
TCMBANKGE008055	ECHDC1	HEL-S-76; MMCD; dJ351K20.2	ethylmalonyl-CoA decarboxylase 1
TCMBANKGE008126	TPI1	HEL-S-49; TIM; TPI; TPID	triosephosphate isomerase 1
TCMBANKGE008251	HIBCH	HIBYLCOAH	3-hydroxyisobutyryl-CoA hydrolase
TCMBANKGE008359	CA8	CA-RP; CA-VIII; CALS; CAMRQ3; CARP	carbonic anhydrase 8
TCMBANKGE008418	ALG11	CDG1P; GT8	ALG11 alpha-1,2-mannosyltransferase
TCMBANKGE008724	CDYL	CDYL1	chromodomain Y like
TCMBANKGE008893	TAT	-	tyrosine aminotransferase
TCMBANKGE009047	CA11	CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1	carbonic anhydrase 11
TCMBANKGE009354	PIGA	GPI3; MCAHS2; PIG-A; PNH1	phosphatidylinositol glycan anchor biosynthesis class A
TCMBANKGE009356	CA7	CA-VII; CAVII	carbonic anhydrase 7
TCMBANKGE009361	GPT	AAT1; ALT1; GPT1	glutamic--pyruvic transaminase
TCMBANKGE009370	LYPLA1	APT-1; APT1; LPL-I; LPL1; hAPT1	lysophospholipase 1
TCMBANKGE009787	ACCSL	-	1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like
TCMBANKGE009800	RPIA	RPI; RPIAD	ribose 5-phosphate isomerase A
TCMBANKGE010079	ADSS1	ADSSL1; MPD5	adenylosuccinate synthase 1
TCMBANKGE010104	LYPLA2	APT-2; APT2; DJ886K2.4	lysophospholipase 2
TCMBANKGE010171	CA13	CAXIII	carbonic anhydrase 13
TCMBANKGE010181	ENOSF1	FUCD; RTS; TYMSAS	enolase superfamily member 1
TCMBANKGE010522	EHHADH	ECHD; FRTS3; L-PBE; LBFP; LBP; PBFE	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
TCMBANKGE011029	DCK	-	deoxycytidine kinase
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE011397	KYAT3	CCBL2; KAT3; KATIII	kynurenine aminotransferase 3
TCMBANKGE011734	HOGA1	C10orf65; DHDPS2; DHDPSL; HP3; NPL2	4-hydroxy-2-oxoglutarate aldolase 1
TCMBANKGE012101	GOT1	AST1; ASTQTL1; GIG18; cAspAT; cCAT	glutamic-oxaloacetic transaminase 1
TCMBANKGE012203	FH	FMRD; HLRCC; HsFH; LRCC; MCL; MCUL1	fumarate hydratase
TCMBANKGE012242	ALG1	CDG1K; HMAT1; HMT-1; HMT1; MT-1; Mat-1; hMat-1	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
TCMBANKGE012450	ECHDC2	-	enoyl-CoA hydratase domain containing 2
TCMBANKGE012572	CA5B	CA-VB; CAVB	carbonic anhydrase 5B
TCMBANKGE012662	PTPRZ1	HPTPZ; HPTPzeta; PTP-ZETA; PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan	protein tyrosine phosphatase receptor type Z1
TCMBANKGE012736	CA9	CAIX; MN	carbonic anhydrase 9
TCMBANKGE012946	CARNS1	ATPGD1	carnosine synthase 1
TCMBANKGE013033	NANS	HEL-S-100; SAS; SEMDCG; SEMDG	N-acetylneuraminate synthase
TCMBANKGE013500	ECHS1	ECHS1D; SCEH	enoyl-CoA hydratase, short chain 1
TCMBANKGE014015	BCHE	BCHED; CHE1; CHE2; E1	butyrylcholinesterase
TCMBANKGE014050	GABRA1	ECA4; EIEE19; EJM; EJM5	gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014168	ECI2	ACBD2; DRS-1; DRS1; HCA88; PECI; dJ1013A10.3	enoyl-CoA delta isomerase 2
TCMBANKGE014208	CAD	CDG1Z; EIEE50; GATD4	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
TCMBANKGE014280	JAG1	AGS; AGS1; AHD; AWS; CD339; DCHE; HJ1; JAGL1	jagged canonical Notch ligand 1
TCMBANKGE014313	KYAT1	CCBL1; GTK; KAT1; KATI	kynurenine aminotransferase 1
TCMBANKGE014656	ABAT	GABA-AT; GABAT; NPD009	4-aminobutyrate aminotransferase
TCMBANKGE014847	PUDP	DXF68S1E; FAM16AX; GS1; HDHD1; HDHD1A	pseudouridine 5'-phosphatase