Compound Summary

  Compound Information

TCMBANKIN060029

药名:	parthenolide
分子式:	C15H20O3
Smiles:	CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
成分:	HBIN038876; HBIN038877
SymMap_id:	SMIT17112
TCMID_id:	16663; 25371
PubChem_id:	124463365

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE001857	Michelia lanuginosa	绒叶含笑
TCMBANKHE002445	Smilax aristolochiaefolia
TCMBANKHE003734	radix tripterygii wilfordii	雷公藤			To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage./Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen.
TCMBANKHE004045	Michelia yunnanensis	云南含笑			To clear heat and resolve toxin./Pharyngolaryngitis, nasitis, conjunctivitis, brain leak.
TCMBANKHE008249	Magnolia praecocissima	皱叶木兰
TCMBANKHE007187/XU-444	Carpesium longifolium	长叶天名精		云南省昭通市永善县
TCMBANKHE005716/YEM-243	Semen Canbis;Fructus Canbis;Fructus cannabis|Cannabis sativa L.	火麻仁;麻子仁|大麻	大麻	云南民族药物志：第二卷	To cause Taxation.;Purging by moisterizing/Blood and liquid depletion, intestinal dry and constipation.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE004249/YEM-671	Michelia champaca|Michelia champaca L.	黄缅桂	黄缅桂	云南民族药物志：第四卷	To dispel wind-damp, disinhibit throat./Wind-damp impediment pain, swelling pain in throat.	傣族/傈僳族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000006	Nasopharyngeal Neoplasms	group	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases	23674500
TCMBANKDI000022	Prostatic Neoplasms	group	Neoplasms; Male Urogenital Diseases	21719790
TCMBANKDI000026	Obesity	disease	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases	31078744
TCMBANKDI000053	leukemia	disease	Neoplasms
TCMBANKDI000069	Bone neoplasms	group	Neoplasms; Musculoskeletal Diseases	28965856
TCMBANKDI000082	Nasopharyngeal carcinoma	disease	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases	23876538
TCMBANKDI000088	Lung Neoplasms	group	Neoplasms; Respiratory Tract Diseases	23507557
TCMBANKDI000090	Acute kidney injury	disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
TCMBANKDI000921	Blood Pressure	phenotype	-
TCMBANKDI001402	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases	29773592
TCMBANKDI008514	Carcinoma	group	Neoplasms	24387758
TCMBANKDI015740	Colorectal Neoplasms	group	Digestive System Diseases; Neoplasms	21321301
TCMBANKDI016139	Endometriosis	disease	Female Urogenital Diseases and Pregnancy Complications	23318959
TCMBANKDI018658	Osteolysis	phenotype	Musculoskeletal Diseases	26821066

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000051	IL1B	IL-1; IL1-BETA; IL1F2; IL1beta	interleukin 1 beta
TCMBANKGE000053	NFKB1	CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB	nuclear factor kappa B subunit 1
TCMBANKGE000199	ICAM1	BB2; CD54; P3.58	intercellular adhesion molecule 1
TCMBANKGE000204	CXCL8	GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8	C-X-C motif chemokine ligand 8
TCMBANKGE000223	KEAP1	INrf2; KLHL19	kelch like ECH associated protein 1
TCMBANKGE000224	AGT	ANHU; SERPINA8; hFLT1	angiotensinogen
TCMBANKGE000315	IL4	BCGF-1; BCGF1; BSF-1; BSF1; IL-4	interleukin 4
TCMBANKGE000331	CALCA	CALC1; CGRP; CGRP-I; CGRP-alpha; CGRP1; CT; KC; PCT	calcitonin related polypeptide alpha
TCMBANKGE000543	OSCAR	PIGR3; PIgR-3	osteoclast associated Ig-like receptor
TCMBANKGE000729	CASP1	ICE; IL1BC; P45	caspase 1
TCMBANKGE000811	KL	HFTC3	klotho
TCMBANKGE000812	REL	C-Rel	REL proto-oncogene, NF-kB subunit
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000814	DPP9	DP9; DPLP9; DPP IX; DPRP-2; DPRP2	dipeptidyl peptidase 9
TCMBANKGE000815	DPP8	DP8; DPRP-1; DPRP1; MST097; MSTP097; MSTP135; MSTP141	dipeptidyl peptidase 8
TCMBANKGE000816	Txn1	ADF; AW550880; Trx1; Txn	thioredoxin 1
TCMBANKGE000817	PGAM5	BXLBV68	PGAM family member 5, mitochondrial serine/threonine protein phosphatase
TCMBANKGE000818	ROS1	MCF3; ROS; c-ros-1	ROS proto-oncogene 1, receptor tyrosine kinase
TCMBANKGE000819	TRPA1	ANKTM1; FEPS; FEPS1	transient receptor potential cation channel subfamily A member 1
TCMBANKGE000820	CFLAR	CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; cFLIP	CASP8 and FADD like apoptosis regulator
TCMBANKGE000821	PMAIP1	APR; NOXA	phorbol-12-myristate-13-acetate-induced protein 1
TCMBANKGE000822	ANXA5	ANX5; ENX2; HEL-S-7; PP4; RPRGL3	annexin A5
TCMBANKGE000823	GABPA	E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07	GA binding protein transcription factor subunit alpha
TCMBANKGE000875	ATF4	CREB-2; CREB2; TAXREB67; TXREB	activating transcription factor 4
TCMBANKGE001014	TNFRSF10B	CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9	TNF receptor superfamily member 10b
TCMBANKGE001030	NOTCH1	AOS5; AOVD1; TAN1; hN1	notch receptor 1
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001085	MAPK8	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c	mitogen-activated protein kinase 8
TCMBANKGE001114	IL6	BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6	interleukin 6
TCMBANKGE001123	CTNNB1	CTNNB; EVR7; MRD19; NEDSDV; armadillo	catenin beta 1
TCMBANKGE001126	NFE2L2	HEBP1; IMDDHH; NRF2; Nrf-2	nuclear factor, erythroid 2 like 2
TCMBANKGE001162	IFNG	IFG; IFI	interferon gamma
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001169	BCL2L1	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52	BCL2 like 1
TCMBANKGE001173	MCL1	BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT	MCL1 apoptosis regulator, BCL2 family member
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001205	DDIT3	AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153	DNA damage inducible transcript 3
TCMBANKGE011739	CTF1	CT-1; CT1	cardiotrophin 1