Compound Summary
Compound Information
药名: | tetrandrine |
别名: | NCI60_042029; IDI1_033949; MLS000728516; Spectrum3_000659; Spectrum2_000025; Prestwick2_000670; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1-beta)- (9CI); NSC77037; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1.beta.)-(PM)-; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)- (9CI); SPECTRUM1504185; Spectrum_000315; BSPBio_001479; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1.beta.)-; Prestwick0_000670; A828808; AIDS-032943; (S,S)-(+)-Tetrandrine; CBiol_001914; 2-27-00-00889 (Beilstein Handbook Reference); T2695_SIGMA; SpecPlus_000661; SMR000445630; KBioGR_001178; Tetrandrine; SDCCGMLS-0066758.P001; NCGC00142549-02; C09654; NSC91771; Spectrum4_000619; SPBio_000089; KBio2_000795; KBio3_000398; D-Tetrandrine; NCGC00142549-01; KBio3_000397; Fanchinine; BSPBio_002297; TETRANDRINE, (DL); Bio1_000200; AIDS032943; KBio2_003363; NCGC00142549-03; Tetrandrin; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)-; (+/-)-Tetrandine; SPBio_002660; DivK1c_006757; tetrandrine ; BPBio1_000813; ST057602; FF-0019; KBioGR_000199; KBio1_001701; Bio2_000679; Spectrum5_001366; KBio2_005931; (.+-.)-Tetrandrine; (1beta)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; 518-34-3; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)- (9CI); KBioSS_000199; KBioSS_000795; (S,S)-()-Tetrandrine; KBio2_000199; (+-)-Tetrandine; DL-Tetrandine; (S,S)-Tetrandrine; NSC 77037; Bio1_000689; DL-Tetrandine; (+)-Tetrandrine; Hanfangchin A; 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinoline; 6-methoxy-2-methyl-1-(phenylmethyl)-3,4-dihydro-1H-isoquinoline; dihydrate; AIDS-027689; BRN 0877811; 365629_ALDRICH; Bio2_000199; Sinomenine A; KBio2_005335; Bio1_001178; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1-beta)-; NSC 91771; AIDS027689; BSPBio_000739; KBio3_001517; DL-Tetandrine; Prestwick3_000670; CCRIS 2705; Prestwick1_000670; 23495-89-8; HSCI1_000014; KBio2_002767; NCI60_041696; (+-)-Tetrandine; NCI60_042029; IDI1_033949; BCP0726000284; MLS000728516; Spectrum3_000659; NCGC00017376-10; AB00513883; S-(+)-Tetrandrine; Spectrum2_000025; HY-13764; (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyc lo[22.6.2.2<3,6>.1<8,12>.1<14,18>.0<22,36>.0<27,31>]hexatriaconta-3(33),4,6(34 ),8(35),9,11,18(36),19,21,24,26,31-dodecaene; HMS3402J21; Prestwick2_000670; NSC77037; HMS1570E21; d-Tetrandr; Tetrandrine, analytical standard, for drug analysis; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)- (9CI); SR-01000779899-6; 29EX23D5AJ; SPECTRUM1504185; Spectrum_000315; BSPBio_001479; BBL029400; CS-0007782; Prestwick0_000670; HMS1791J21; LS-148949; (S,S)-(+)-Tetrandrine; W-2768; 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-; CBiol_001914; Tetrandrine (Fanchinine); 2-27-00-00889 (Beilstein Handbook Reference); SMR000445630; SpecPlus_000661; KBioGR_001178; NCGC00182717-01; AC1L2J88; SDCCGMLS-0066758.P001; UNII-29EX23D5AJ; NCGC00142549-02; C09654; CHEBI:49; NSC91771; Spectrum4_000619; SPBio_000089; KBio2_000795; AC1Q58EO; iso-tetrandrine; HMS1361J21; AS-15343; KBio3_000398; (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyc lo[22.6.2.2<3,6>.1<8,12>.1<14,18>.0<22,36>.0<27,31>]hexatriaconta-3(33),4,6(34 ),8(35),9,11,18(36),19,21,24,26,31-dodecae; D-Tetrandrine; KBio3_000397; NCGC00017376-05; Fanchinine; NCGC00142549-01; Q-100580; BSPBio_002297; Tetrandrine, Millenia Hope; SR-01000779899-7; TETRANDRINE, (DL); (1.beta.)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; ZINC28116057; S,S-(+)-Tetrandrine; Bio1_000200; D0G4ES; KBio2_003363; NCGC00142549-03; SR-01000779899; Tetrandrine, European Pharmacopoeia (EP) Reference Standard; 6490-80-8; D0AN2Q; BRD-8237; Tetrandrin; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)-; HMS2097E21; 916770-74-6; CCG-38342; (+/-)-Tetrandine; HMS1989J21; Berbaman,6',7,12-trtramethoxy-2,2'-dimethyl-, (1.beta.)-(PM)-; SPBio_002660; Tetrandrine - Fanchinine; NCGC00017376-06; DivK1c_006757; 6,6',7,12-tetramethoxy-2,2'-dimethyl-1 beta-berbaman; BB_NC-1040; Tetrandrine, West Virginia University; BPBio1_000813; ST057602; STK801908; FF-0019; KBioGR_000199; AB0016761; NSC-77037; KBio1_001701; 607379-81-7; Bio2_000679; Isotetrandrine; Spectrum5_001366; KBio2_005931; (.+-.)-Tetrandrine; (1beta)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; 518-34-3; BRD-K08078237-001-07-3; Tetrandrine(Fanchinine); SR-01000779899-5; CHEMBL176045; DTXSID10178062; KBioSS_000199; NCGC00017376-04; tetradrine; MLS002153946; S2403; (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{14,18}.0^{27,31}.0^{22,33}]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24,26,31,35-dodecaene; KBioSS_000795; (1S,14S)-9,20,21,25-TETRAMETHOXY-15,30-DIMETHYL-7,23-DIOXA-15,30-DIAZAHEPTACYCLO[22.6.2.2_,?.1?,__.1_?,_?.0_?,__.0__,__]HEXATRIACONTA-3,5,8(34),9,11,18(33),19,21,24,26,31,35-DODECAENE; SCHEMBL20119; tetrandrine; KBio2_000199; AN-8470; O972; C38H42N2O6; (S,S)-Tetrandrine; NSC 77037; Bio1_000689; DL-Tetrandine; NCGC00142549-04; (+)-Tetrandrine; BG00889113; HMS2232C06; Hanfangchin A; 518T343; BRN 0877811; (11S,31S)-16,36,37,54-tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane; MCULE-2548279289; Bio2_000199; AC-7987; Berbaman, 6,6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(+-)-; Sinomenine A; KBio2_005335; MFCD08689909; Tranex-18; SR-01000779899-9; WVTKBKWTSCPRNU-KYJUHHDHSA-N; Bio1_001178; Berbaman,6',7,12-tetramethoxy-2,2'-dimethyl-, (1.beta.)-; MolPort-000-763-034; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1-beta)-; NSC 91771; BSPBio_000739; Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-; NCGC00017376-03; KBio3_001517; hanjisong; DL-Tetandrine; SC-14047; Prestwick3_000670; NCGC00017376-02; tetramethoxy(dimethyl)[?]; CCRIS 2705; Prestwick1_000670; AKOS004119881; BRD8237; 23495-89-8; HSCI1_000014; KBio2_002767; NSC-91771; NCI60_041696; (+-)-Tetrandine; hanfangchin a |
分子式: | C38H42N2O6 |
Smiles: | CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC |
成分: | HBIN046110; HBIN028783 |
OB_score: | 26.639741 |
CAS_id: | 518-34-3 |
SymMap_id: | SMIT00150; SMIT02038 |
TCMID_id: | 21190; 24187 |
TCMSP_id: | MOL002343 |
PubChem_id: | 73078 |
DrugBank_id: | DB14066 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE000689 | Cera Flava | 蜂蜡 | Treatment of ulcer difficulty to heal, wounds, burns and scalds./Treatment of ulcer difficulty to heal, wounds, burns and scalds. | |||
| TCMBANKHE001044 | Radix Stephaniae Tetrandrae | 粉防己 | For arthralgia, especially of heat type, also for acrodynia of dampness-heat type, trauma, periarthritis of joint and angina pectoris. For edema nad dysuria. In ancient times, used for dyspneic cough due to withered lung or heat-heat, for hemoptysis with abundant expectoration due to withered lung, used together with Semen Lepidii seu Descurainiae. Recently, use for bronchial asthma, asthmatic bronchitis, silicosis, pulmonary tuberculosis, etc. For hypertension, especially that complicated by coronary heart diseases. For carcinoma of lung, and squamous cell epithioma(decreasing the dosage of radiotherapy by one-third to one-fourth and minimizing the occurrence of side effect)./1. Hanfangchin A and B are two active components, which have an anti-inflammatory effect.2. Anti-allergic, inhibiting the release of histamine.3. Promting phagocytosis.4. Dilating coronary artery and decreasing myocardial oxygen consumption.5. Inhibiting the growth of Bacillus tuberculosis, Staphylococcus aureus and ameba.6. High dosage may induce respiratory inhibition and cardiac arrest. | |||
| TCMBANKHE002981 | Nidus Vespae | 蜂房 | Treatment of toothache due to caries, sores, ulcers, mastitis, scrofula, ringworm, tinea unguium./Treatment of toothache due to caries, sores, ulcers, mastitis, scrofula, ringworm, tinea unguium. | |||
| TCMBANKHE007156 | Herba Patriniae | 败酱草 | 1. To eliminate heat and toxic material, relieve abscess and promote pus drainage. 2. To remove blood stasis and alleviate pain/1. Two active components, patrinene and isopatrinene, possess sedative effect. 2. To promote regeneration of hepatic cells and portal circulation, protect hepatic cells from degernation and improve hepatic function. | |||
| TCMBANKHE003748 | Rhizoma Coptidis | 黄连 | To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds. | |||
| TCMBANKHE003782 | Fructus Corni | 山茱萸 | To replenish the liver and kidney, restrain seminal discharge and relieve collapse./Dizziness and tinnitus, aching in lumbus and knees, impotence and emission, enuresis and frequent urination, flooding and spotting with vaginal discharge, vacuity and profuse sweating, vacuity desertion due to great sweating, diabetes mellitus due to internal heat, dysmenorrhea. | |||
| TCMBANKHE005790 | Menispermum dauricum | 蝙蝠葛根 | To clear heat and resolve toxin, disperse swelling and relieve pain, disinhibit damp./Swelling pain in throat, lung heat cough, epidemic parotitis, diarrhea, jaundice, wind-damp impediment pain, swelling pain from hemorrhoids, snake or insect bites. | |||
| TCMBANKHE004121 | Radix Stemoe | 百部 | 1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie. | |||
| TCMBANKHE006056 | Rhizoma Menispermi | 北豆根 | To remove toxic heat and relieve rheumatic pains./Treatment of sore throat, colitis, dysentery, rheumatic arthralgia. | |||
| TCMBANKHE004407 | Stephania discolor | 蔡文千金藤 | ||||
| TCMBANKHE004460 | Cissampelos pareira | 锡生藤 | To relieve pain, stanch bleeding, engender flesh./Knocks and falls, asthma, heart disease. | |||
| TCMBANKHE004664 | Radix Codonopsis pilosulae | 党参 | To reinforce qi and invigorate the function of the spleen and the lung./Spleen-stomach vacuity, reduced food intake and sloppy stool, lassitude in limbs, cough and asthma due to lung vacuity, shortness of breath and spontaneous sweating, qi-blood depletion. | |||
| TCMBANKHE004953 | Aristolochia debilis [Syn. Aristolochia longa ] | 青木香 | To lower blood pressure, calm liver and relieve pain, resolve toxin and disperse swelling./Hypertension, gastrospasm, stomachache, infections, chronic bone marrow infection, chronic bronchitis, infection of skin, dizziness and headache, distending pain in chest and abdomen, swollen welling abscess and clove sores, snake or insect bites. | |||
| TCMBANKHE005181 | Cyclea racemosa | 轮环藤 | To rectify qi and relieve pain, dispel damp and resolve toxin./Distending pain in chest and stomach duct, abdominal pain and diarrhea, wind-damp pain, throat pain, poisonous snake bite, dog bite, swelling toxin of welling abscess and flat abscess, bleeding due to external injury. | |||
| TCMBANKHE005259 | Aristolochia heterophylla | 汉防己 | To dispel wind and relieve pain, clear heat and disinhibit water./Rheumatic pain in joints, damp-heat pain in limbs, edema, inhibited urination, beriberi with edema. | |||
| TCMBANKHE006371 | 白屈菜 | Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites. | ||||
| TCMBANKHE009013 | Cortex Illicii | 地枫皮 | To relieve rheumatic conditions, and to promote the flow of qi and relieve pain./Pain in joints due to rheumatalgia, taxation damage in lumbar muscle, centipede bite. | |||
| TCMBANKHE006145 | Anser cygnoides domestica | 鹅膵 | Otitis media, deafness. | |||
| TCMBANKHE007036 | Cyclea barbata | 银不换 | To clear heat and resolve toxin, disperse stasis and relieve pain, disinhibit urine and free strangury./Wind-heat common cold, throat pain, toothache, stomachache, abdominal pain, damp-heat dysentery, malaria, dribbling pain of urination, painful wound from knocks and falls, sprain and contusion. | |||
| TCMBANKHE009133 | Radix Codonopsis pilosulae | 西党;党参 | Treatment of weakness of the spleen and the lung manifested by shortness of breath, cough, palpitation, anorexia, loose stools, diabetes caused by internal heat;To reinforce qi and invigorate the function of the spleen and the lung./Treatment of weakness of the spleen and the lung manifested by shortness of breath, cough, palpitation, anorexia, loose stools, diabetes caused by internal heat;Spleen-stomach vacuity, reduced food intake and sloppy stool, lassitude in limbs, cough and asthma due to lung vacuity, shortness of breath and spontaneous sweating, qi-blood depletion. | |||
| TCMBANKHE006744 | Menispermum dauricum | 蝙蝠葛 | To clear heat and resolve toxin, disperse swelling and relieve pain./Lumbago, scrofula, swelling pain in throat, diarrhea and dysentery, swelling pain from hemorrhoids. | |||
| TCMBANKHE007238 | Radix Stephaniae Tetrandrae | 防己 | To cause diuresis and to relieve rheumatic conditions./Beriberi with edema, inhibited urination, eczema, sore toxin, wind-damp impediment pain, hypertension, adjuvant in anesthesia. | |||
| TCMBANKHE007928 | 白药子 | Septicemia, acute hepatitis, bacillary dysentery, parotitis, neurodermatitis, swelling pain in throat, heat toxin swollen welling abscess, wind-damp impediment pain, abdominal pain and diarrhea, blood ejection, bleeding, spontaneous external bleeding, bleeding due to external injury. |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI000013 | Bone Resorption | phenotype | Musculoskeletal Diseases | 30674869 |
| TCMBANKDI000018 | Pancreatic Neoplasm | disease | Digestive System Diseases; Neoplasms; Endocrine System Diseases | 29605511 |
| TCMBANKDI000048 | Neoplasms | group | Neoplasms | 29866132 |
| TCMBANKDI000053 | leukemia | disease | Neoplasms | 29700286 |
| TCMBANKDI008221 | Arthritis | disease | Musculoskeletal Diseases | 30674869 |
| TCMBANKDI015496 | Liver neoplasms | group | Digestive System Diseases; Neoplasms | 29334999 |
| TCMBANKDI027673 | Arthritis, Experimental | disease | Musculoskeletal Diseases | 29401630 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000247 | SLC2A4 | GLUT4 | solute carrier family 2 member 4 |
| TCMBANKGE000264 | ABCB1 | ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 | ATP binding cassette subfamily B member 1 |
| TCMBANKGE000294 | CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | cyclin dependent kinase inhibitor 1A |
| TCMBANKGE000315 | IL4 | BCGF-1; BCGF1; BSF-1; BSF1; IL-4 | interleukin 4 |
| TCMBANKGE000479 | TIMP1 | CLGI; EPA; EPO; HCI; TIMP; TIMP-1 | TIMP metallopeptidase inhibitor 1 |
| TCMBANKGE000486 | IL2RA | CD25; IDDM10; IL2R; IMD41; TCGFR; p55 | interleukin 2 receptor subunit alpha |
| TCMBANKGE000742 | SMAD7 | CRCS3; MADH7; MADH8 | SMAD family member 7 |
| TCMBANKGE000938 | CDK2 | CDKN2; p33(CDK2) | cyclin dependent kinase 2 |
| TCMBANKGE001013 | BIRC5 | API4; EPR-1 | baculoviral IAP repeat containing 5 |
| TCMBANKGE001045 | CCND1 | BCL1; D11S287E; PRAD1; U21B31 | cyclin D1 |
| TCMBANKGE001047 | E2F1 | E2F-1; RBAP1; RBBP3; RBP3 | E2F transcription factor 1 |
| TCMBANKGE001098 | NFKBIA | EDAID2; IKBA; MAD-3; NFKBI | NFKB inhibitor alpha |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001161 | IL2 | IL-2; TCGF; lymphokine | interleukin 2 |
| TCMBANKGE001162 | IFNG | IFG; IFI | interferon gamma |
| TCMBANKGE001166 | BCL2 | Bcl-2; PPP1R50 | BCL2 apoptosis regulator |
| TCMBANKGE001170 | CDK4 | CMM3; PSK-J3 | cyclin dependent kinase 4 |
| TCMBANKGE001177 | TP53 | BCC7; BMFS5; LFS1; P53; TRP53 | tumor protein p53 |
| TCMBANKGE001179 | SMAD2 | JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2 | SMAD family member 2 |
| TCMBANKGE001180 | SMAD3 | HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3 | SMAD family member 3 |
| TCMBANKGE001181 | TGFB1 | CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta | transforming growth factor beta 1 |
| TCMBANKGE001184 | RELA | CMCU; NFKB3; p65 | RELA proto-oncogene, NF-kB subunit |
| TCMBANKGE001197 | FOS | AP-1; C-FOS; p55 | Fos proto-oncogene, AP-1 transcription factor subunit |
| TCMBANKGE006248 | FCER2 | BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF | Fc fragment of IgE receptor II |
| TCMBANKGE009956 | LITAF | PIG7; SIMPLE; TP53I7 | lipopolysaccharide induced TNF factor |
| TCMBANKGE010213 | HERC5 | CEB1; CEBP1 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
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